真菌中的一氧化氮：产生与功能

Nitric Oxide in Fungi: Production and Function.

作者信息

Yu Nan-Nan, Park Gyungsoon

机构信息

Plasma Bioscience Research Center, Department of Plasma-Bio Display, Kwangwoon University, Seoul 01897, Republic of Korea.

Department of Electrical and Biological Physics, Kwangwoon University, Seoul 01897, Republic of Korea.

出版信息

J Fungi (Basel). 2024 Feb 15;10(2):155. doi: 10.3390/jof10020155.

DOI:10.3390/jof10020155

PMID:38392826

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10889981/

Abstract

Nitric oxide (NO) is synthesized in all kingdoms of life, where it plays a role in the regulation of various physiological and developmental processes. In terms of endogenous NO biology, fungi have been less well researched than mammals, plants, and bacteria. In this review, we summarize and discuss the studies to date on intracellular NO biosynthesis and function in fungi. Two mechanisms for NO biosynthesis, NO synthase (NOS)-mediated arginine oxidation and nitrate- and nitrite-reductase-mediated nitrite reduction, are the most frequently reported. Furthermore, we summarize the multifaceted functions of NO in fungi as well as its role as a signaling molecule in fungal growth regulation, development, abiotic stress, virulence regulation, and metabolism. Finally, we present potential directions for future research on fungal NO biology.

摘要

一氧化氮（NO）在所有生物界中都有合成，它在各种生理和发育过程的调节中发挥作用。就内源性NO生物学而言，与哺乳动物、植物和细菌相比，真菌的研究较少。在这篇综述中，我们总结并讨论了迄今为止关于真菌细胞内NO生物合成和功能的研究。最常报道的NO生物合成的两种机制是：一氧化氮合酶（NOS）介导的精氨酸氧化以及硝酸盐和亚硝酸盐还原酶介导的亚硝酸盐还原。此外，我们总结了NO在真菌中的多方面功能，以及它作为信号分子在真菌生长调节、发育、非生物胁迫、毒力调节和代谢中的作用。最后，我们提出了真菌NO生物学未来研究的潜在方向。