Department of Stomatology, Chengdu Seventh People's Hospital, Chengdu, 610044, China.
Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Curr Med Sci. 2024 Feb;44(1):232-240. doi: 10.1007/s11596-024-2828-8. Epub 2024 Feb 23.
Secoemestrin C (SC), an epitetrathiodioxopiperazine isolated from Aspergillus nidulans, has been previously reported to have immunomodulatory and hepatoprotective effects against acute autoimmune hepatitis. However, the effect of SC on regulating the inflammation and its underlying mechanisms in the pathogenesis of psoriasis remain unclear. This study aimed to evaluate the effects of SC on inflammatory dermatosis both in vitro and in vivo.
In vitro, HaCaT cells were induced with tumor necrosis factor-alpha (TNF-α, 10 ng/mL) to establish an inflammatory injury model, and the expression of nuclear transcription factor-κB (NF-κB) pathway components was measured using qRT-PCR and Western blotting. An in vivo mouse model of imiquimod (IMQ)-induced psoriasis-like skin inflammation was used to evaluate the effectiveness of SC in alleviating psoriasis.
SC significantly blocked the activation of NF-κB signaling in TNF-α-stimulated HaCaT cells. In addition, systemic and local administration of SC improved psoriatic dermatitis in the IMQ-induced mouse model. SC reduced skin scale and significantly inhibited the secretion of inflammatory factors in skin lesions.
The protective effect of SC against psoriatic-associated inflammation reveals its potential therapeutic value for treating psoriasis.
Secoemestrin C（SC）是从构巢曲霉中分离得到的一种表硫代二氧哌嗪，具有免疫调节和肝保护作用，可对抗急性自身免疫性肝炎。然而，SC 对调节银屑病发病机制中的炎症及其潜在机制的影响尚不清楚。本研究旨在评估 SC 在体内和体外对炎症性皮肤病的作用。
体外，用肿瘤坏死因子-α（TNF-α，10ng/ml）诱导 HaCaT 细胞建立炎症损伤模型，并用 qRT-PCR 和 Western blot 测定核转录因子-κB（NF-κB）途径成分的表达。采用咪喹莫特（IMQ）诱导的银屑病样皮肤炎症小鼠模型评价 SC 减轻银屑病的效果。
SC 显著阻断了 TNF-α 刺激的 HaCaT 细胞中 NF-κB 信号的激活。此外，SC 的全身和局部给药改善了 IMQ 诱导的小鼠模型中的银屑病样皮炎。SC 减少了皮肤鳞屑，显著抑制了皮肤病变中炎症因子的分泌。
SC 对银屑病相关炎症的保护作用表明其在治疗银屑病方面具有潜在的治疗价值。
