Gulf Medical University, Ajman, United Arab Emirates.
Manipal Academy of Higher Education, Manipal, Karnataka, India.
PLoS One. 2024 Feb 23;19(2):e0297110. doi: 10.1371/journal.pone.0297110. eCollection 2024.
The purpose of this study was to test the diagnostic accuracy of the 10g monofilament to screen for diabetic peripheral neuropathy (DPN) in India. The study further assessed the effect of physical activity, footwear use, and occupation on the outcome.
Non-probabilistic purposive sampling was used to recruit patients with T2DM to assess the diagnostic utility of the 10 g monofilament. 160 participants were recruited divided into 4 groups. Each group consisted of 40 participants with 20 under each category described as "Physical Worker Vs Non- physical worker" (n = 40), "Barefoot Vs Footwear" (n = 40), "Use of Slipper at Home Vs No-slippers use at home" (n = 40), "Agriculture Vs Non- agriculture" (n = 40). 10 g monofilament was used to detect the presence of protective sensation towards screening of DPN against biothesiometer (Vibration Pressure Threshold).
The area under the ROC (receiver operating characteristic) curve was 0.6 for identifying DPN using the 10 g monofilament. Physical work (p = 0.04), footwear (p = 0.04), slipper use at home (p = 0.02) and occupation (p = 0.02) impacted on the diagnostic utility of the 10g monofilament.
This study shows that the 10 g monofilament has limited accuracy for detecting DPN in the Indian population and this is further affected by occupation, socioeconomic and religious practice.
本研究旨在检验 10g 单丝检测印度糖尿病周围神经病变（DPN）的诊断准确性。本研究进一步评估了身体活动、穿鞋和职业对结果的影响。
采用非概率目的性抽样招募 T2DM 患者，评估 10g 单丝的诊断效用。招募了 160 名参与者，分为 4 组。每组 40 人，分为“体力劳动者与非体力劳动者”（n=40）、“赤脚与穿鞋”（n=40）、“在家穿拖鞋与不穿拖鞋”（n=40）和“农业与非农业”（n=40）。使用 10g 单丝检测保护性感觉，筛查 DPN 对抗生物测振仪（振动压力阈值）。
ROC（接受者操作特征）曲线下面积为 0.6，表明 10g 单丝可用于识别 DPN。体力劳动（p=0.04）、穿鞋（p=0.04）、在家穿拖鞋（p=0.02）和职业（p=0.02）影响 10g 单丝的诊断效用。
本研究表明，10g 单丝在检测印度人群 DPN 方面准确性有限，且受职业、社会经济和宗教实践的影响。
