Andersen W A, Sabio H, Durso N, Mills S E, Levien M, Underwood P B
Cancer. 1985 Sep 1;56(5):1025-7. doi: 10.1002/1097-0142(19850901)56:5<1025::aid-cncr2820560509>3.0.co;2-x.
Endodermal sinus tumor of the vagina, a rare pediatric malignancy, was managed with primary chemotherapy (vincristine, dactinomycin, cyclophosphamide [VAC]) followed by local excision without radical surgery or pelvic irradiation. Treatment-related complications were acceptable, and there is no evidence of disease 30 months after discontinuing all therapy (50 months after diagnosis). As a treatment option, primary chemotherapy is viewed as a highly attractive alternative modality, preserving potential reproductive and sexual function in long-term survivors, and appears to be the treatment of choice.
阴道内胚窦瘤是一种罕见的儿童恶性肿瘤，采用了初始化疗（长春新碱、放线菌素D、环磷酰胺[VAC]），随后进行局部切除，未行根治性手术或盆腔放疗。治疗相关并发症可接受，在停止所有治疗后30个月（诊断后50个月）无疾病证据。作为一种治疗选择，初始化疗被视为一种极具吸引力的替代方式，可保留长期存活者的潜在生殖和性功能，似乎是首选治疗方法。
