Zoology Department, Faculty of Science, Cairo University, Cairo, Egypt.
Bioinformatics Group Center of Informatics Science, Nile University, Giza, Egypt.
J Psychiatr Res. 2024 Apr;172:171-180. doi: 10.1016/j.jpsychires.2024.02.029. Epub 2024 Feb 17.
Depression is the most prevalent psychiatric disorder worldwide. Although numerous antidepressant treatments are available, there is a serious clinical concern due to their severe side effects and the fact that some depressed patients are resistant to them. Lithium is the drug of choice for bipolar depression and has been used as adjunct therapy with other groups of antidepressants.
The present study aims to investigate the effect of lithium augmentation with cerebrolysin on the neurochemical, behavioral and histopathological alterations induced in the reserpine model of depression.
The animals were divided into control and reserpine-induced model of depression. The model animals were further divided into rat model of depression, rat model treated with lithium, rat model treated with cerebrolysin and rat model treated with a combination of lithium and cerebrolysin.
Treatment with lithium, cerebrolysin, or their combination alleviated most of the changes in behavior, oxidative stress parameters, acetylcholinesterase and monoamines in the cortex and hippocampus of the reserpine-induced model of depression. It also improved the alterations in brain-derived neurotrophic factor (BDNF) and histopathology induced by reserpine.
The augmentation of lithium with cerebrolysin showed a clear beneficial effect in the present model of depression suggesting the use of cerebrolysin as an adjuvant in antidepressant treatment.
抑郁症是全球最普遍的精神疾病。尽管有许多抗抑郁药物可供选择，但由于其严重的副作用，以及一些抑郁症患者对此类药物有抗药性，这仍是一个严重的临床问题。锂是双相抑郁症的首选药物，已被用作其他抗抑郁药物的辅助治疗。
本研究旨在探讨脑活素联合锂治疗对利血平诱导的抑郁症模型的神经化学、行为和组织病理学改变的影响。
将动物分为对照组和利血平诱导的抑郁症模型组。将模型动物进一步分为抑郁症大鼠模型、锂治疗大鼠模型、脑活素治疗大鼠模型和锂与脑活素联合治疗大鼠模型。
锂、脑活素或两者联合治疗缓解了利血平诱导的抑郁症模型皮质和海马中单胺氧化酶、乙酰胆碱酯酶、氧化应激参数以及行为的大部分变化，并改善了利血平诱导的脑源性神经营养因子（BDNF）和组织病理学的改变。
脑活素联合锂治疗在本抑郁症模型中表现出明显的有益作用，提示脑活素可作为抗抑郁治疗的辅助药物。
