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Myo-inositol-1-phosphate synthase from streptomyces griseus (studies on the biosynthesis of cyclitols, XXXVIII).

作者信息

Pittner F, Tovarova I I, Kornitskaya E Y, Khokhlov A S, Hoffmann-Ostenhof O

出版信息

Mol Cell Biochem. 1979 May 6;25(1):43-6. doi: 10.1007/BF00211140.

DOI:10.1007/BF00211140
PMID:38395
Abstract

It could be shown that Streptomyces griseus, the microorganism producing the antibiotic streptomycin and also mutant strains of this species that cannot synthesize streptomycin, possess myo-inositol-1-phosphate synthase (EC 5.5.1.4), the enzyme cyclizing D-glucose 6-phosphate. The enzyme isolated from that organism is extremely instable, its molecular weight is approximately 260,000, and it requires a divalent metal ion for its activity. This is the first instance that an enzyme of this specificity has been found in a prokaryotic organism.

摘要

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1
Myo-inositol-1-phosphate synthase from streptomyces griseus (studies on the biosynthesis of cyclitols, XXXVIII).
Mol Cell Biochem. 1979 May 6;25(1):43-6. doi: 10.1007/BF00211140.
2
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Hoppe Seylers Z Physiol Chem. 1978 May;359(5):613-6.
5
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Investigations on myo-inositol-1-phosphate synthase from the wild type and the inositol-dependent mutant of Neurospora crassa.对粗糙脉孢菌野生型和肌醇依赖型突变体的肌醇-1-磷酸合酶的研究。
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Biosynthesis of streptomycin. dTDP-dihydrostreptose synthase from Streptomyces griseus and dTDP-4-keto-L-rhamnose 3,5-epimerase from S. griseus and Escherichia coli Y10.链霉素的生物合成。来自灰色链霉菌的dTDP-二氢链霉糖合酶以及来自灰色链霉菌和大肠杆菌Y10的dTDP-4-酮基-L-鼠李糖3,5-表异构酶。
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2
Preparation of homogeneous crystals of myo-inositol 1-phosphate synthase from rat testicles--further data on the chemical and catalytic properties of the enzyme (studies on the biosynthesis cyclitols, XXXIX).大鼠睾丸中肌醇-1-磷酸合酶均一晶体的制备——关于该酶化学和催化性质的更多数据（环醇生物合成研究，XXXIX）
Mol Cell Biochem. 1979 Dec 14;28(1-3):23-6. doi: 10.1007/BF00223357.

本文引用的文献

1
Enzymatic synthesis of streptidine from scyllo-inosamine.由异肌醇胺酶促合成链霉胍。
Biochemistry. 1967 Dec;6(12):3821-9. doi: 10.1021/bi00864a028.
2
Studies on the streptomycin biosynthesis.
Postepy Hig Med Dosw. 1972 Jul-Aug;26(4):469-91.
3
Biosynthesis of myo-inositol in rat mammary gland. Isolation and properties of the enzymes.大鼠乳腺中肌醇的生物合成。酶的分离与特性
Arch Biochem Biophys. 1974 Sep;164(1):194-201. doi: 10.1016/0003-9861(74)90022-8.
4
A colorimetric determination of inositol monophosphates as an assay for D-glucose 6-phosphate-1L-myoinositol 1-phosphate cyclase.一种比色法测定肌醇单磷酸酯，作为6-磷酸-D-葡萄糖-1L-肌醇1-磷酸环化酶的一种测定方法。
Biochem J. 1970 Sep;119(2):183-6. doi: 10.1042/bj1190183.
5
The mechanism of glucose 6-phosphate-D-myo-inositol 1-phosphate cyclase of rat testis. The involvement of hydrogen atoms.大鼠睾丸中葡萄糖6-磷酸-D-肌醇1-磷酸环化酶的机制。氢原子的参与。
Biochem J. 1968 Jun;108(1):125-9. doi: 10.1042/bj1080125.
6
Studies on the biosynthesis of cyclitols, XXXV. On the mechanism of action of myo-inositol-1-phosphate synthase from rat testicles.
Hoppe Seylers Z Physiol Chem. 1976 Dec;357(12):1667-71. doi: 10.1515/bchm2.1976.357.2.1667.
7
[Biosynthesis of myoinositol and its incorporation into the phospholipids of Escherichia coli].[肌醇的生物合成及其掺入大肠杆菌磷脂的过程]
Z Allg Mikrobiol. 1976;16(1):81-3. doi: 10.1002/jobm.3630160112.
8
Studies on the biosynthesis of cyclitols, XXXVII. On mechanism and function of Schiff's base formation as an intermediary reaction step of myo-inositol-1-phosphate synthase from rat testicles.环多元醇的生物合成研究，XXXVII。关于席夫碱形成作为大鼠睾丸肌醇-1-磷酸合酶中间反应步骤的机制和功能。
Hoppe Seylers Z Physiol Chem. 1978 Oct;359(10):1395-400. doi: 10.1515/bchm2.1978.359.2.1395.