Courtney C H, Shearer J K, Plue R E
Am J Vet Res. 1985 Jun;46(6):1245-6.
The safety and anthelmintic efficacy of clorsulon (7 mg/kg of body weight, orally) given concurrently with ivermectin (0.2 mg/kg, subcutaneously) for control of Fasciola hepatica were evaluated in 75 crossbred beef cattle. Twenty-three control animals were given only ivermectin. Fluke egg counts were significantly lower (P less than 0.0001) in clorsulon-treated animals by day 14 after treatment than before treatment (base line) and were significantly lower (P less than 0.005) after treatment in clorsulon-treated animals than in controls. There was no significant change in fluke egg counts of controls after treatment. The efficacy of clorsulon in reducing F hepatica egg counts was 99%. Clorsulon showed poor efficacy against paramphistomes. Adverse reactions were not observed.
在75头杂交肉牛中评估了同时给予氯舒隆（7毫克/千克体重，口服）和伊维菌素（0.2毫克/千克，皮下注射）以控制肝片吸虫的安全性和驱虫效果。23头对照动物仅给予伊维菌素。在治疗后第14天，氯舒隆治疗的动物的吸虫卵计数比治疗前（基线）显著降低（P小于0.0001），且氯舒隆治疗的动物治疗后的吸虫卵计数显著低于对照组（P小于0.005）。治疗后对照组的吸虫卵计数没有显著变化。氯舒隆减少肝片吸虫卵计数的效果为99%。氯舒隆对双口吸虫的效果不佳。未观察到不良反应。
