肥胖或1型糖尿病儿童及青少年体内的单核细胞趋化蛋白-1（MCP-1）、激活素A和簇集蛋白
Monocyte Chemoattractant Protein-1 (MCP-1), Activin-A and Clusterin in Children and Adolescents with Obesity or Type-1 Diabetes Mellitus.
作者信息
Kostopoulou Eirini, Kalavrizioti Dimitra, Davoulou Panagiota, Papachristou Evangelos, Sinopidis Xenophon, Fouzas Sotirios, Dassios Theodore, Gkentzi Despoina, Kyriakou Stavroula Ioanna, Karatza Ageliki, Dimitriou Gabriel, Goumenos Dimitrios, Spiliotis Bessie E, Plotas Panagiotis, Papasotiriou Marios
机构信息
Division of Pediatric Endocrinology, Department of Pediatrics, University Hospital of Patras, School of Medicine, University of Patras, 26504 Patras, Greece.
Department of Nephrology and Kidney Transplantation, University Hospital of Patras, School of Medicine, University of Patras, 26504 Patras, Greece.
出版信息
Diagnostics (Basel). 2024 Feb 19;14(4):450. doi: 10.3390/diagnostics14040450.
UNLABELLED
Inflammation plays a crucial role in diabetes and obesity through macrophage activation. Macrophage chemoattractant protein-1 (MCP-1), activin-A, and clusterin are chemokines with known roles in diabetes and obesity. The aim of this study is to investigate their possible diagnostic and/or early prognostic values in children and adolescents with obesity and type-1 diabetes mellitus (T1DM).
METHODS
We obtained serum samples from children and adolescents with a history of T1DM or obesity, in order to measure and compare MCP-1, activin-A, and clusterin concentrations.
RESULTS
Forty-three subjects were included in each of the three groups (controls, T1DM, and obesity). MCP-1 values were positively correlated to BMI z-score. Activin-A was increased in children with obesity compared to the control group. A trend for higher values was detected in children with T1DM. MCP-1 and activin-A levels were positively correlated. Clusterin levels showed a trend towards lower values in children with T1DM or obesity compared to the control group and were negatively correlated to renal function.
CONCLUSIONS
The inflammation markers MCP-1, activin-A, and clusterin are not altered in children with T1DM. Conversely, obesity in children is positively correlated to serum MCP-1 values and characterized by higher activin-A levels, which may reflect an already established systematic inflammation with obesity since childhood.
未标记
炎症通过巨噬细胞激活在糖尿病和肥胖症中起关键作用。巨噬细胞趋化因子蛋白-1（MCP-1）、激活素-A和簇集蛋白是在糖尿病和肥胖症中具有已知作用的趋化因子。本研究的目的是调查它们在肥胖儿童和青少年以及1型糖尿病（T1DM）患者中可能的诊断和/或早期预后价值。
方法
我们采集了有T1DM或肥胖病史的儿童和青少年的血清样本，以测量和比较MCP-1、激活素-A和簇集蛋白的浓度。
结果
三组（对照组、T1DM组和肥胖组）每组均纳入43名受试者。MCP-1值与BMI z评分呈正相关。与对照组相比，肥胖儿童的激活素-A升高。在T1DM儿童中检测到有更高值的趋势。MCP-1和激活素-A水平呈正相关。与对照组相比，T1DM或肥胖儿童的簇集蛋白水平呈降低趋势，且与肾功能呈负相关。
结论
炎症标志物MCP-1、激活素-A和簇集蛋白在T1DM儿童中未发生改变。相反，儿童肥胖与血清MCP-1值呈正相关，其特征是激活素-A水平较高，这可能反映了自儿童期起肥胖就已存在的系统性炎症。
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