Department of Biology Education, Daegu University, 201, Daegudae-ro, Gyeongsan-si 38453, Gyeongsangbuk-do, Republic of Korea.
Int J Mol Sci. 2024 Feb 9;25(4):2129. doi: 10.3390/ijms25042129.
ATP-sensitive potassium (KATP) channels are found in plasma membranes and mitochondria. These channels are a type of ion channel that is regulated by the intracellular concentration of adenosine triphosphate (ATP) and other nucleotides. In cell membranes, they play a crucial role in linking metabolic activity to electrical activity, especially in tissues like the heart and pancreas. In mitochondria, KATP channels are involved in protecting cells against ischemic damage and regulating mitochondrial function. This review delves into the role of KATP channels in cancer biology, underscoring their critical function. Notably responsive to changes in cellular metabolism, KATP channels link metabolic states to electrical activity, a feature that becomes particularly significant in cancer cells. These cells, characterized by uncontrolled growth, necessitate unique metabolic and signaling pathways, differing fundamentally from normal cells. Our review explores the intricate roles of KATP channels in influencing the metabolic and ionic balance within cancerous cells, detailing their structural and operational mechanisms. We highlight the channels' impact on cancer cell survival, proliferation, and the potential of KATP channels as therapeutic targets in oncology. This includes the challenges in targeting these channels due to their widespread presence in various tissues and the need for personalized treatment strategies. By integrating molecular biology, physiology, and pharmacology perspectives, the review aims to enhance the understanding of cancer as a complex metabolic disease and to open new research and treatment avenues by focusing on KATP channels. This comprehensive approach provides valuable insights into the potential of KATP channels in developing innovative cancer treatments.
三磷酸腺苷敏感性钾 (KATP) 通道存在于质膜和线粒体中。这些通道是一种离子通道，受细胞内三磷酸腺苷 (ATP) 和其他核苷酸浓度的调节。在细胞膜中，它们在将代谢活动与电活动联系起来方面发挥着至关重要的作用，特别是在心脏和胰腺等组织中。在线粒体中，KATP 通道参与保护细胞免受缺血性损伤和调节线粒体功能。本综述深入探讨了 KATP 通道在癌症生物学中的作用，强调了其关键功能。值得注意的是，KATP 通道对细胞代谢变化非常敏感，将代谢状态与电活动联系起来，这一特性在癌细胞中变得尤为重要。这些细胞的特征是不受控制的生长，需要独特的代谢和信号通路，与正常细胞有根本的不同。我们的综述探讨了 KATP 通道在影响癌细胞内代谢和离子平衡方面的复杂作用，详细描述了它们的结构和操作机制。我们强调了通道对癌细胞存活、增殖的影响，以及 KATP 通道作为肿瘤学治疗靶点的潜力。这包括由于这些通道在各种组织中广泛存在以及需要个性化治疗策略而靶向这些通道的挑战。通过整合分子生物学、生理学和药理学的观点，该综述旨在增强对癌症作为一种复杂代谢疾病的理解，并通过关注 KATP 通道为研究和治疗开辟新的途径。这种综合方法为开发创新的癌症治疗方法提供了有价值的见解。
