宫内暴露于糖尿病是否会影响心理和运动技能？贝利婴幼儿发育量表的荟萃分析。
Does Intrauterine Exposure to Diabetes Impact Mental and Motor Skills? A Meta-Analysis of the Bayley Scales of Infant Development.
机构信息
Maternal and Child Nursing Department, School of Nursing, The University of Jordan, Amman 11942, Jordan.
The Centre for Evidence Informed Nursing, Midwifery and Healthcare Practice, Joondalup 6027, Australia.
出版信息
Int J Environ Res Public Health. 2024 Feb 7;21(2):191. doi: 10.3390/ijerph21020191.
BACKGROUND
Attempts to conduct meta-analyses of the association between child development and diabetes have been limited by the wide range of tools and definitions of developmental outcomes used in the literature. We aim to meta-analyze a widely used measure of child development, the Bayley Scales of Infant Development, with respect to exposure to diabetes and developmental scores.
METHODS
PsycINFO, MEDLINE/PubMed, EMBASE, Emcare, and Google Scholar databases were searched. Two independent reviewers screened, extracted, and quality-appraised the studies using JBI SUMARI software. Forest plots were created with the standardized mean difference using the random-effects model, and heterogeneity was assessed using .
RESULTS
Seven studies were identified. The pooled results on psychomotor and mental development index mean scores were lower for infants born to mothers with diabetes than for the control group (Cohen's d = -4.49, df = 7, = 0%, = 0.001 and Cohen's d = -3.4, df = 9, = 27%, = 0.001, respectively). Effects were larger in infants born to mothers with type 1 and 2 diabetes and at age 12 months.
CONCLUSIONS
Maternal diabetes should be considered as a risk factor for children's development, mainly when born to mothers with pre-existing diabetes.
背景
由于文献中用于发育结果的工具和定义范围广泛，尝试对儿童发育与糖尿病之间的关联进行荟萃分析受到了限制。我们旨在对广泛使用的儿童发育评估工具——贝利婴幼儿发育量表进行荟萃分析，评估其与糖尿病暴露和发育评分的关系。
方法
在 PsycINFO、MEDLINE/PubMed、EMBASE、Emcare 和 Google Scholar 数据库中进行检索。两名独立的审查员使用 JBI SUMARI 软件筛选、提取和评估研究的质量。使用随机效应模型创建具有标准化均数差值的森林图，并使用 评估异质性。
结果
确定了 7 项研究。与对照组相比，患有糖尿病的母亲所生婴儿的精神运动和智力发育指数平均得分较低（Cohen's d = -4.49，df = 7， = 0%， = 0.001 和 Cohen's d = -3.4，df = 9， = 27%， = 0.001）。在患有 1 型和 2 型糖尿病的母亲所生的婴儿和在 12 个月大时，效果更大。
结论
应将母亲的糖尿病视为儿童发育的危险因素，尤其是在患有糖尿病的母亲所生的婴儿中。
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