Panga Mogellah John, Zhao Ye
School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing 211816, China.
Antioxidants (Basel). 2024 Jan 29;13(2):173. doi: 10.3390/antiox13020173.
Zinc pyrithione (ZPT), a widely utilized industrial chemical, is recognized for its versatile properties, including antimicrobial, antibacterial, antifungal, and antifouling activities. Despite its widespread use, recent research has shed light on its toxicity, particularly towards the male reproductive system. While investigations into ZPT's impact on male reproduction have been conducted, most of the attention has been directed towards marine organisms. Notably, ZPT has been identified as a catalyst for oxidative stress, contributing to various indicators of male infertility, such as a reduced sperm count, impaired sperm motility, diminished testosterone levels, apoptosis, and degenerative changes in the testicular tissue. Furthermore, discussions surrounding ZPT's effects on DNA and cellular structures have emerged. Despite the abundance of information regarding reproductive toxicity, the molecular mechanisms underlying ZPT's detrimental effects on the male reproductive system remain poorly understood. This review focuses specifically on ZPT, delving into its reported toxicity on male reproduction, while also addressing the broader context by discussing other antifouling chemicals, and emphasizing the need for further exploration into its molecular mechanisms.
吡啶硫酮锌（ZPT）是一种广泛使用的工业化学品，因其具有多种特性而闻名，包括抗菌、抗细菌、抗真菌和防污活性。尽管其应用广泛，但最近的研究揭示了它的毒性，尤其是对男性生殖系统的毒性。虽然已经对ZPT对男性生殖的影响进行了调查，但大部分注意力都集中在海洋生物上。值得注意的是，ZPT已被确定为氧化应激的催化剂，导致男性不育的各种指标，如精子数量减少、精子活力受损、睾酮水平降低、细胞凋亡以及睾丸组织的退行性变化。此外，围绕ZPT对DNA和细胞结构影响的讨论也已出现。尽管有大量关于生殖毒性的信息，但ZPT对男性生殖系统产生有害影响的分子机制仍知之甚少。本综述特别关注ZPT，深入探讨其对男性生殖的毒性报道，同时通过讨论其他防污化学品来阐述更广泛的背景，并强调需要进一步探索其分子机制。
