Bolognesi Andrea, Bortolotti Massimo, Battelli Maria Giulia, Polito Letizia
Department of Medical and Surgical Sciences-DIMEC, Alma Mater Studiorum, University of Bologna, Via San Giacomo 14, 40126 Bologna, Italy.
Antioxidants (Basel). 2024 Feb 7;13(2):211. doi: 10.3390/antiox13020211.
Taking into account the patient's gender is the first step towards more precise and egalitarian medicine. The gender-related divergences observed in purine catabolism and their pathological consequences are good examples of gender medicine differences. Uric acid is produced by the activity of xanthine oxidoreductase (XOR). The serum levels of both XOR activity and uric acid differ physiologically between the genders, being higher in men than in women. Their higher levels have been associated with gout and hypertension, as well as with vascular, cardiac, renal, and metabolic diseases. The present review analyzes the gender-related differences in these pathological conditions in relation to increases in the serum levels of XOR and/or uric acid and the opportunity for gender-driven pharmacological treatment.
考虑患者的性别是迈向更精确和平等医学的第一步。在嘌呤代谢中观察到的与性别相关的差异及其病理后果是性别医学差异的很好例证。尿酸是由黄嘌呤氧化还原酶（XOR）的活性产生的。XOR活性和尿酸的血清水平在生理上存在性别差异，男性高于女性。它们的较高水平与痛风、高血压以及血管、心脏、肾脏和代谢疾病有关。本综述分析了这些病理状况中与性别相关的差异，涉及XOR和/或尿酸血清水平的升高以及性别驱动的药物治疗机会。
