凝血与心房颤动之间的关联。

The Association between Coagulation and Atrial Fibrillation.

作者信息

Rafaqat Saira, Gluscevic Sanja, Patoulias Dimitrios, Sharif Saima, Klisic Aleksandra

机构信息

Department of Zoology (Molecular Physiology), Lahore College for Women University, Lahore 54600, Punjab, Pakistan.

Department of Neurology, Clinical Center of Montenegro, 81000 Podgorica, Montenegro.

出版信息

Biomedicines. 2024 Jan 25;12(2):274. doi: 10.3390/biomedicines12020274.

DOI:10.3390/biomedicines12020274

PMID:38397876

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10887311/

Abstract

The existing literature highlights the presence of numerous coagulation factors and markers. Elevated levels of coagulation factors are associated with both existing and newly diagnosed cases of atrial fibrillation (AF). However, this article summarizes the role of coagulation in the pathogenesis of AF, which includes fibrinogen and fibrin, prothrombin, thrombomodulin, soluble urokinase plasminogen activator receptor, von Willebrand factor, P-selectin, D-dimer, plasminogen activator inhibitor-1, and platelet activation. Coagulation irregularities play a significant role in the pathogenesis of AF.

摘要

现有文献强调了众多凝血因子和标志物的存在。凝血因子水平升高与心房颤动（AF）的现有病例和新诊断病例均相关。然而，本文总结了凝血在房颤发病机制中的作用，其中包括纤维蛋白原和纤维蛋白、凝血酶原、血栓调节蛋白、可溶性尿激酶型纤溶酶原激活物受体、血管性血友病因子、P-选择素、D-二聚体、纤溶酶原激活物抑制剂-1以及血小板活化。凝血异常在房颤发病机制中起着重要作用。