Institute of Zoology, University of Punjab, Quaid-I-Azam Campus, Lahore, Pakistan.
Department of the Zoology, Lahore College for Women University, Lahore, Pakistan.
Curr Heart Fail Rep. 2024 Aug;21(4):277-291. doi: 10.1007/s11897-024-00671-z. Epub 2024 Jun 13.
This article summarizes the role of coagulation factors in the pathophysiology of heart failure including D-dimer, fibrinogen and fibrin, prothrombin, p-selectin, tissue factor, tissue plasminogen activator, von Willebrand factor, β-thromboglobulin, Factor XI, tissue thromboplastin, plasminogen activator inhibitor-1 (PAI-1), thrombomodulin, soluble urokinase-type plasminogen activator receptor (suPAR) and stuart-prower factor.
The D-dimer, P-selectin, prothrombin, von Willebrand factor, tissue plasminogen activator, fibrinogen, suPAR, tissue factor, thrombomodulin and Factor XI play significant roles the pathophysiology of heart failure. However, no associations were found between β-thromboglobulin, tissue thromboplastin, PAI-1 and stuart-prower factor in the context of heart failure. Coagulation factors play significant role in the pathophysiology of heart failure. Consequently, the underlying pathophysiological mechanisms that explain changes in the cascade are closely related to the diagnostic, prognostic and therapeutic roles of coagulation cascade factors, which help physicians identify and treat heart failure.
本文总结了凝血因子在心力衰竭的病理生理学中的作用，包括 D-二聚体、纤维蛋白原和纤维蛋白、凝血酶原、p-选择素、组织因子、组织型纤溶酶原激活物、血管性血友病因子、β-血栓球蛋白、因子 XI、组织型纤溶酶原激活物抑制剂-1（PAI-1）、血栓调节蛋白、可溶性尿激酶型纤溶酶原激活物受体（suPAR）和 Stuart-Prower 因子。
D-二聚体、p-选择素、凝血酶原、血管性血友病因子、组织型纤溶酶原激活物、纤维蛋白原、suPAR、组织因子、血栓调节蛋白和因子 XI 在心力衰竭的病理生理学中起着重要作用。然而，β-血栓球蛋白、组织因子、PAI-1 和 Stuart-Prower 因子与心力衰竭之间没有关联。凝血因子在心力衰竭的病理生理学中起着重要作用。因此，解释级联变化的潜在病理生理机制与凝血级联因子的诊断、预后和治疗作用密切相关，这有助于医生识别和治疗心力衰竭。
