Kapat Kausik, Kumbhakarn Sakshi, Sable Rahul, Gondane Prashil, Takle Shruti, Maity Pritiprasanna
Department of Medical Devices, National Institute of Pharmaceutical Education and Research Kolkata, 168, Maniktala Main Road, Kankurgachi, Kolkata 700054, West Bengal, India.
Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC 29425, USA.
Biomedicines. 2024 Jan 29;12(2):313. doi: 10.3390/biomedicines12020313.
The healing of osteochondral defects (OCDs) that result from injury, osteochondritis, or osteoarthritis and bear lesions in the cartilage and bone, pain, and loss of joint function in middle- and old-age individuals presents challenges to clinical practitioners because of non-regenerative cartilage and the limitations of current therapies. Bioactive peptide-based osteochondral (OC) tissue regeneration is becoming more popular because it does not have the immunogenicity, misfolding, or denaturation problems associated with original proteins. Periodically, reviews are published on the regeneration of bone and cartilage separately; however, none of them addressed the simultaneous healing of these tissues in the complicated heterogeneous environment of the osteochondral (OC) interface. As regulators of cell adhesion, proliferation, differentiation, angiogenesis, immunomodulation, and antibacterial activity, potential therapeutic strategies for OCDs utilizing bone and cartilage-specific peptides should be examined and investigated. The main goal of this review was to study how they contribute to the healing of OCDs, either alone or in conjunction with other peptides and biomaterials.
因损伤、骨软骨炎或骨关节炎导致的骨软骨缺损（OCD），在中老年人的软骨和骨骼中出现病变、疼痛以及关节功能丧失，由于软骨无法再生以及当前治疗方法的局限性，给临床医生带来了挑战。基于生物活性肽的骨软骨（OC）组织再生越来越受欢迎，因为它不存在与原始蛋白质相关的免疫原性、错误折叠或变性问题。定期会分别发表关于骨和软骨再生的综述；然而，它们都没有涉及在骨软骨（OC）界面复杂的异质环境中这些组织的同时愈合。作为细胞黏附、增殖、分化、血管生成、免疫调节和抗菌活性的调节剂，利用骨和软骨特异性肽治疗OCD的潜在策略应予以研究和探讨。本综述的主要目的是研究它们如何单独或与其他肽和生物材料联合促进OCD的愈合。
