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用于软骨和软骨下骨界面再生的生物活性支架。

Bioactive Scaffolds for Regeneration of Cartilage and Subchondral Bone Interface.

机构信息

State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences. Shanghai 200050,P.R.China.

University of Chinese Academy of Sciences, Beijing 100049, P.R.China.

出版信息

Theranostics. 2018 Feb 15;8(7):1940-1955. doi: 10.7150/thno.23674. eCollection 2018.

DOI:10.7150/thno.23674
PMID:29556366
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5858510/
Abstract

The cartilage lesion resulting from osteoarthritis (OA) always extends into subchondral bone. It is of great importance for simultaneous regeneration of two tissues of cartilage and subchondral bone. 3D-printed Sr(PO)SiO (SPS) bioactive ceramic scaffolds may achieve the aim of regenerating both of cartilage and subchondral bone. We hypothesized that strontium (Sr) and silicon (Si) ions released from SPS scaffolds play a crucial role in osteochondral defect reconstruction. SPS bioactive ceramic scaffolds were fabricated by a 3D-printing method. The SEM and ICPAES were used to investigate the physicochemical properties of SPS scaffolds. The proliferation and maturation of rabbit chondrocytes stimulated by SPS bioactive ceramics were measured . The stimulatory effect of SPS scaffolds for cartilage and subchondral bone regeneration was investigated . SPS scaffolds significantly stimulated chondrocyte proliferation, and SPS extracts distinctly enhanced the maturation of chondrocytes and preserved chondrocytes from OA. SPS scaffolds markedly promoted the regeneration of osteochondral defects. The complex interface microstructure between cartilage and subchondral bone was obviously reconstructed. The underlying mechanism may be related to Sr and Si ions stimulating cartilage regeneration by activating HIF pathway and promoting subchondral bone reconstruction through activating Wnt pathway, as well as preserving chondrocytes from OA via inducing autophagy and inhibiting hedgehog pathway. Our findings suggest that SPS scaffolds can help osteochondral defect reconstruction and well reconstruct the complex interface between cartilage and subchondral bone, which represents a promising strategy for osteochondral defect regeneration.

摘要

骨关节炎（OA）引起的软骨损伤总是延伸到软骨下骨。同时再生软骨和软骨下骨两种组织非常重要。3D 打印 Sr(PO)SiO（SPS）生物活性陶瓷支架可能实现再生软骨和软骨下骨的目的。我们假设 SPS 支架释放的锶（Sr）和硅（Si）离子在骨软骨缺损重建中发挥关键作用。采用 3D 打印方法制备 SPS 生物活性陶瓷支架。使用 SEM 和 ICPAES 研究 SPS 支架的物理化学性质。测量 SPS 生物活性陶瓷对兔软骨细胞增殖和成熟的刺激作用。研究 SPS 支架对软骨和软骨下骨再生的刺激作用。SPS 支架显著刺激软骨细胞增殖，SPS 提取物明显增强软骨细胞的成熟，并防止 OA 软骨细胞发生。SPS 支架明显促进骨软骨缺损的再生。软骨和软骨下骨之间的复杂界面微观结构明显重建。潜在的机制可能与 Sr 和 Si 离子通过激活 HIF 途径刺激软骨再生以及通过激活 Wnt 途径促进软骨下骨重建有关，还通过诱导自噬和抑制 Hedgehog 途径来保护 OA 软骨细胞。我们的研究结果表明，SPS 支架有助于骨软骨缺损的重建，并很好地重建了软骨和软骨下骨之间的复杂界面，这代表了骨软骨缺损再生的一种有前途的策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0834/5858510/fe1b35c96f2d/thnov08p1940g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0834/5858510/a928813457dd/thnov08p1940g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0834/5858510/61705a78f5bb/thnov08p1940g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0834/5858510/b54ef52906b0/thnov08p1940g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0834/5858510/9b1c08aec8e2/thnov08p1940g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0834/5858510/605ec77d5076/thnov08p1940g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0834/5858510/1030cfe3cfad/thnov08p1940g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0834/5858510/17cf30b28109/thnov08p1940g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0834/5858510/fe9a5b2fde83/thnov08p1940g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0834/5858510/3f7f1cf7c57d/thnov08p1940g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0834/5858510/0fcb938c91b9/thnov08p1940g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0834/5858510/fe1b35c96f2d/thnov08p1940g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0834/5858510/a928813457dd/thnov08p1940g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0834/5858510/61705a78f5bb/thnov08p1940g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0834/5858510/b54ef52906b0/thnov08p1940g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0834/5858510/9b1c08aec8e2/thnov08p1940g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0834/5858510/605ec77d5076/thnov08p1940g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0834/5858510/1030cfe3cfad/thnov08p1940g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0834/5858510/17cf30b28109/thnov08p1940g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0834/5858510/fe9a5b2fde83/thnov08p1940g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0834/5858510/3f7f1cf7c57d/thnov08p1940g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0834/5858510/0fcb938c91b9/thnov08p1940g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0834/5858510/fe1b35c96f2d/thnov08p1940g011.jpg

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本文引用的文献

[1]
Bone-Inspired Spatially Specific Piezoelectricity Induces Bone Regeneration.

Theranostics. 2017-8-11

[2]
Drug-Bearing Supramolecular Filament Hydrogels as Anti-Inflammatory Agents.

Theranostics. 2017-5-12

[3]
Structurally and Functionally Optimized Silk-Fibroin-Gelatin Scaffold Using 3D Printing to Repair Cartilage Injury In Vitro and In Vivo.

Adv Mater. 2017-6-6

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Biol Trace Elem Res. 2017-4-29

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Theranostics. 2017-2-27

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Adv Mater. 2017-2-10

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Theranostics. 2017-1-1

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Am J Transl Res. 2016-11-15

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Low-intensity pulsed ultrasound (LIPUS) treatment of cultured chondrocytes stimulates production of CCN family protein 2 (CCN2), a protein involved in the regeneration of articular cartilage: mechanism underlying this stimulation.

Osteoarthritis Cartilage. 2017-5

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Proc Natl Acad Sci U S A. 2016-5-10

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