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糖尿病与妊娠：对表观基因组影响的洞察

Diabetes Mellitus and Pregnancy: An Insight into the Effects on the Epigenome.

作者信息

Meza-León Andrea, Montoya-Estrada Araceli, Reyes-Muñoz Enrique, Romo-Yáñez José

机构信息

Coordinación de Endocrinología Ginecológica y Perinatal, Instituto Nacional de Perinatología, Montes Urales 800, Lomas Virreyes, Mexico City 11000, Mexico.

出版信息

Biomedicines. 2024 Feb 2;12(2):351. doi: 10.3390/biomedicines12020351.

DOI:10.3390/biomedicines12020351
PMID:38397953
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10886464/
Abstract

Worldwide, diabetes mellitus represents a growing health problem. If it occurs during pregnancy, it can increase the risk of various abnormalities in early and advanced life stages of exposed individuals due to fetal programming occurring in utero. Studies have determined that maternal conditions interfere with the genotypes and phenotypes of offspring. Researchers are now uncovering the mechanisms by which epigenetic alterations caused by diabetes affect the expression of genes and, therefore, the development of various diseases. Among the numerous possible epigenetic changes in this regard, the most studied to date are DNA methylation and hydroxymethylation, as well as histone acetylation and methylation. This review article addresses critical findings in epigenetic studies involving diabetes mellitus, including variations reported in the expression of specific genes and their transgenerational effects.

摘要

在全球范围内，糖尿病是一个日益严重的健康问题。如果糖尿病发生在孕期，由于子宫内的胎儿编程，它会增加暴露个体在生命早期和晚期出现各种异常的风险。研究已确定母体状况会干扰后代的基因型和表型。研究人员目前正在揭示糖尿病引起的表观遗传改变影响基因表达进而影响各种疾病发生发展的机制。在这方面众多可能的表观遗传变化中，迄今为止研究最多的是DNA甲基化和羟甲基化，以及组蛋白乙酰化和甲基化。这篇综述文章阐述了糖尿病表观遗传学研究中的关键发现，包括特定基因表达的变化及其跨代效应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e619/10886464/4a47a98fd5b2/biomedicines-12-00351-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e619/10886464/dffbb8cc406e/biomedicines-12-00351-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e619/10886464/5b574e0c2b68/biomedicines-12-00351-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e619/10886464/4a47a98fd5b2/biomedicines-12-00351-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e619/10886464/dffbb8cc406e/biomedicines-12-00351-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e619/10886464/5b574e0c2b68/biomedicines-12-00351-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e619/10886464/4a47a98fd5b2/biomedicines-12-00351-g003.jpg

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本文引用的文献

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Aberrant lipid accumulation in the mouse visceral yolk sac resulting from maternal diabetes and obesity.母体糖尿病和肥胖导致小鼠内脏卵黄囊中脂质异常蓄积。
Front Cell Dev Biol. 2023 Mar 1;11:1073807. doi: 10.3389/fcell.2023.1073807. eCollection 2023.
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Methylation of histone H3 lysine 4 is required for maintenance of beta cell function in adult mice.
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Int J Mol Sci. 2024 Oct 30;25(21):11641. doi: 10.3390/ijms252111641.
组蛋白 H3 赖氨酸 4 的甲基化对于成年小鼠胰岛β细胞功能的维持是必需的。
Diabetologia. 2023 Jun;66(6):1097-1115. doi: 10.1007/s00125-023-05896-6. Epub 2023 Mar 13.
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Analysis of Pregnancy Complications and Epigenetic Gestational Age of Newborns.分析妊娠并发症与新生儿表观遗传胎龄。
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