Klitgaard Allan, Ibsen Rikke, Lykkegaard Jesper, Hilberg Ole, Løkke Anders
Department of Regional Health Research, University of Southern Denmark, 5230 Odense, Denmark.
Department of Internal Medicine Vejle, University Hospital of Southern Denmark, 7100 Vejle, Denmark.
Biomedicines. 2024 Feb 5;12(2):372. doi: 10.3390/biomedicines12020372.
Recommendations for the treatment of chronic obstructive pulmonary disease (COPD) have shifted towards a more restrictive use of inhaled corticosteroids (ICS). We aimed to identify the nationwide development over time in the use of ICS treatment in COPD. We conducted a register-based repeated cross-sectional study using Danish nationwide registers. On a yearly basis from 1998 to 2018, we included all patients in Denmark ≥ 40 years of age with an ICD-10 diagnosis of COPD (J44). Accumulated ICS use was calculated for each year based on redeemed prescriptions. Patients were divided into the following groups: No ICS, low-dose ICS, medium-dose ICS, or high-dose ICS. From 1998 to 2018, the yearly proportion of patients without ICS treatment increased (from 50.6% to 57.6%), the proportion of patients on low-dose ICS treatment increased (from 11.3% to 14.9%), and the proportion of patients on high-dose ICS treatment decreased (from 17.0% to 9.4%). We demonstrated a national reduction in the use of ICS treatment in COPD from 1998 to 2018, with an increase in the proportion of patients without ICS and on low-dose ICS treatment and a decrease in the proportion of patients on high-dose ICS treatment.
慢性阻塞性肺疾病（COPD）的治疗建议已转向更严格地使用吸入性糖皮质激素（ICS）。我们旨在确定全国范围内COPD患者使用ICS治疗随时间的变化情况。我们使用丹麦全国登记册进行了一项基于登记册的重复横断面研究。在1998年至2018年期间，我们每年纳入丹麦所有年龄≥40岁且ICD-10诊断为COPD（J44）的患者。根据已兑换的处方计算每年的ICS累计使用量。患者分为以下几组：未使用ICS、低剂量ICS、中等剂量ICS或高剂量ICS。从1998年到2018年，未接受ICS治疗的患者年比例增加（从50.6%增至57.6%），接受低剂量ICS治疗的患者比例增加（从11.3%增至14.9%），而接受高剂量ICS治疗的患者比例下降（从17.0%降至9.4%）。我们证明，从1998年到2018年，全国范围内COPD患者使用ICS治疗的情况有所减少，未使用ICS和接受低剂量ICS治疗的患者比例增加，而接受高剂量ICS治疗的患者比例下降。
