Rammos Aidonis, Bechlioulis Aris, Kekiopoulou Areti, Kekiopoulos Pavlos, Katsouras Christos S, Sioka Chrissa
2nd Department of Cardiology, University Hospital of Ioannina, 45110 Ioannina, Greece.
Department of Nuclear Medicine, University Hospital of Ioannina, 45110 Ioannina, Greece.
Life (Basel). 2024 Feb 16;14(2):261. doi: 10.3390/life14020261.
Inflammation is an important mechanism in atherosclerosis and plaque formation. C-reactive protein (CRP) is a common inflammatory biomarker associated with the risk of coronary heart disease. We investigated the relationship of CRP with findings from myocardial perfusion imaging (MPI).
In this retrospective study, 102 consecutive patients (mean age 71 years, 68% males) who underwent MPI (for diagnostic reasons or quantification of myocardial ischemia) and CRP determination (upper limit: 6 mg/L) within 1 month from MPI were included. The patients had no infection or recent acute coronary syndrome.
The median CRP level was 4 mg/L (2, 10) among the study population. Patients with raised CRP had higher summed stress score (SSS) ( = 0.006) and summed rest score (SRS) ( = 0.001) and higher risk for SSS > 3 (OR 9.25, 95% CI 2.03-42.13, = 0.001) compared to those with low CRP. The association of SSS and SRS with CRP levels was more evident in patients over 70 years ( = 0.027 and = 0.005, respectively). No significant difference in summed difference score was shown. The two groups had no difference in other risk factors ( > 0.05 for all comparisons).
a high level of CRP was associated with the presence and extent of stress-induced myocardial ischemia in MPI.
炎症是动脉粥样硬化和斑块形成的重要机制。C反应蛋白（CRP）是一种与冠心病风险相关的常见炎症生物标志物。我们研究了CRP与心肌灌注成像（MPI）结果之间的关系。
在这项回顾性研究中，纳入了102例连续患者（平均年龄71岁，68%为男性），这些患者在MPI检查后1个月内接受了MPI（用于诊断或量化心肌缺血）和CRP测定（上限：6mg/L）。患者无感染或近期急性冠状动脉综合征。
研究人群中CRP的中位数水平为4mg/L（2，10）。与CRP水平低的患者相比，CRP升高的患者有更高的总应激评分（SSS）（P = 0.006）和总静息评分（SRS）（P = 0.001），且SSS>3的风险更高（OR 9.25，95%CI 2.03 - 42.13，P = 0.001）。在70岁以上的患者中，SSS和SRS与CRP水平的关联更为明显（分别为P = 0.027和P = 0.005）。总差异评分无显著差异。两组在其他危险因素方面无差异（所有比较P>0.05）。
高水平的CRP与MPI中应激诱导的心肌缺血的存在和程度相关。
