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两株犬疱疹病毒 1 （CaHV-1）分离株的全基因组测序及法国斗牛犬幼犬感染的临床病理结果。

Whole-Genome Sequencing of Two Canine Herpesvirus 1 (CaHV-1) Isolates and Clinicopathological Outcomes of Infection in French Bulldog Puppies.

机构信息

Istituto Zooprofilattico Sperimentale della Sardegna, 07100 Sassari, Italy.

BMR Genomics s.r.l., 35131 Padova, Italy.

出版信息

Viruses. 2024 Jan 30;16(2):209. doi: 10.3390/v16020209.

DOI:10.3390/v16020209
PMID:38399985
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10893542/
Abstract

(CaHV-1) infects dogs, causing neonatal death and ocular, neurological, respiratory, and reproductive problems in adults. Although CaHV-1 is widespread in canine populations, only four studies have focused on the CaHV-1 whole genome. In such context, two CaHV-1 strains from both the kidney and spleen of 20-day-old deceased French Bulldog puppies were recently isolated in Sardinia, Italy. The extracted viral DNA underwent whole-genome sequencing using the Illumina MiSeq platform. The Italian CaHV-1 genomes were nearly identical (>99%), shared the same tree branch, and clustered near the ELAL-1 (MW353125) and BTU-1 (KX828242) strains, enlarging the completely separated clade discussed by Lewin et al., in 2020. This study aims to provide new insights on the evolution of the CaHV-1, based on high-resolution whole-genome phylogenetic analysis, and on its clinicopathological characterization during a fatal outbreak in puppies.

摘要

(CaHV-1) 感染犬科动物，导致幼犬死亡，并使成年犬出现眼部、神经、呼吸和生殖问题。尽管 CaHV-1 在犬群中广泛存在，但仅有四项研究关注 CaHV-1 的全基因组。在此背景下，意大利撒丁岛最近从两只 20 天大死亡法国斗牛犬幼犬的肾脏和脾脏中分离出了两种 CaHV-1 毒株。提取的病毒 DNA 使用 Illumina MiSeq 平台进行了全基因组测序。意大利 CaHV-1 基因组几乎完全相同（>99%），共享同一树分支，与 ELAL-1 (MW353125) 和 BTU-1 (KX828242) 毒株聚类，扩大了 Lewin 等人在 2020 年讨论的完全分离的进化枝。本研究旨在通过高分辨率全基因组系统发育分析，以及在幼犬致命性爆发期间对其临床病理特征进行分析，为 CaHV-1 的进化提供新的见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3882/10893542/073760db4148/viruses-16-00209-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3882/10893542/8002d84fe39e/viruses-16-00209-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3882/10893542/75aceaa4b016/viruses-16-00209-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3882/10893542/651ac17564f6/viruses-16-00209-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3882/10893542/9d7e7d087f7c/viruses-16-00209-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3882/10893542/411680090379/viruses-16-00209-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3882/10893542/ca348174492a/viruses-16-00209-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3882/10893542/073760db4148/viruses-16-00209-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3882/10893542/8002d84fe39e/viruses-16-00209-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3882/10893542/75aceaa4b016/viruses-16-00209-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3882/10893542/651ac17564f6/viruses-16-00209-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3882/10893542/9d7e7d087f7c/viruses-16-00209-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3882/10893542/411680090379/viruses-16-00209-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3882/10893542/ca348174492a/viruses-16-00209-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3882/10893542/073760db4148/viruses-16-00209-g007.jpg

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