Arkin C F, Millard M, Medeiros L J
Arch Pathol Lab Med. 1985 Oct;109(10):960-1.
We present a case of epidermoid cholesteatoma that killed the patient by relentless invasion, despite radical surgery. An autopsy disclosed a focus of dural and cerebellar invasion, which dramatized the aggressive nature of this disease. In fact, the epithelial cells of this disease are not thought to possess the ability to invade. Instead, inflammation is believed to both stimulate the squamous epithelial cells to proliferate and destroy adjacent tissues, thereby providing a pathway for epithelial cell migration. Epidermoid cholesteatoma, then, is a disease in which the processes of inflammation and hyperplasia combine to mimic a neoplasm.
我们报告一例表皮样胆脂瘤病例，尽管进行了根治性手术，但该肿瘤因持续侵袭导致患者死亡。尸检发现硬脑膜和小脑有受侵病灶，突显了这种疾病的侵袭性。实际上，这种疾病的上皮细胞一般被认为不具备侵袭能力。相反，炎症被认为既能刺激鳞状上皮细胞增殖，又能破坏邻近组织，从而为上皮细胞迁移提供途径。因此，表皮样胆脂瘤是一种炎症和增生过程相结合、类似肿瘤的疾病。
