Maeda N
Biochem Genet. 1985 Jun;23(5-6):455-64. doi: 10.1007/BF00499086.
DNA studies suggest that six loci control the synthesis of human salivary proline-rich proteins (PRPs). Genes at two of these loci (proposed names, PRH1 and PRH2) contain regions that strongly hybridize to a probe made from a cDNA in which sites for the restriction enzyme HaeIII occur repeatedly; they code for the acidic PRPs. Genes at the remaining four loci (PRB1, PRB2, PRB3, and PRB4) contain regions that strongly hybridize to a probe with repeated BstN1 sites; they probably code for the basic and glycosylated PRPs. In contrast to these data suggesting six loci forming two gene subfamilies, studies of protein polymorphisms and families have led to the postulation of 13 loci with 11 common null alleles. The discrepancy in the number of loci is partly resolved by the hypothesis that the three acidic PRPs, Db, Pa, and PIF, are coded for by alleles at one of the HaeIII-type loci rather than by three discrete loci.
DNA研究表明，有六个基因座控制人类富含脯氨酸唾液蛋白（PRP）的合成。其中两个基因座（暂定名称为PRH1和PRH2）的基因包含与由一个cDNA制成的探针强烈杂交的区域，在该cDNA中，限制性内切酶HaeIII的位点反复出现；它们编码酸性PRP。其余四个基因座（PRB1、PRB2、PRB3和PRB4）的基因包含与具有重复BstN1位点的探针强烈杂交的区域；它们可能编码碱性和糖基化PRP。与这些表明六个基因座形成两个基因亚家族的数据相反，对蛋白质多态性和家族的研究导致推测有13个基因座和11个常见的无效等位基因。基因座数量上的差异部分通过以下假设得到解决，即三种酸性PRP，Db、Pa和PIF，由HaeIII型基因座之一的等位基因编码，而不是由三个离散的基因座编码。
