乙酰胆碱作用于M2型毒蕈碱受体，以兴奋大鼠蓝斑神经元。
Acetylcholine acts on m2-muscarinic receptors to excite rat locus coeruleus neurones.
作者信息
Egan T M, North R A
出版信息
Br J Pharmacol. 1985 Aug;85(4):733-5. doi: 10.1111/j.1476-5381.1985.tb11070.x.
Abstract
Intracellular recordings were made from neurones of the rat locus coeruleus in vitro. Acetylcholine increased the firing rate by depolarizing the membrane; both muscarinic and nicotinic antagonists partially reduced this effect. In hexamethonium, pirenzepine shifted the acetylcholine dose-response curve to the right with an equilibrium dissociation constant of 200 nM, indicating an interaction with a m2-type of muscarinic receptor.
摘要
在体外对大鼠蓝斑核神经元进行细胞内记录。乙酰胆碱通过使膜去极化来提高放电频率；毒蕈碱型和烟碱型拮抗剂均可部分减弱这种效应。在六甲铵存在的情况下，哌仑西平使乙酰胆碱剂量反应曲线右移，平衡解离常数为200 nM，表明其与毒蕈碱型m2受体相互作用。
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