Filep J, Frölich J C, Fejes-Tóth G
Clin Exp Hypertens A. 1985;7(7):1007-14. doi: 10.3109/10641968509077245.
The role of vasopressin (VP) in maintaining blood pressure in malignant two-kidney one-clip Goldblatt hypertension in chronically catheterized conscious rats was investigated by studying the effect of two structurally different VP pressor antagonists. Injections of either 20 micrograms/kg of dPTyr(Me)AVP or 10 micrograms/kg of d(CH2)5Tyr(Me)AVP failed to alter mean arterial pressure or heart rate, although both antagonists completely inhibited the pressor response elicited by exogenous VP. These results suggest, that VP is not involved as a pressor hormone in the maintenance of high blood pressure in this type of experimental hypertension.
通过研究两种结构不同的血管加压素（VP）升压拮抗剂的作用，探讨了VP在慢性插管清醒大鼠恶性二肾一夹Goldblatt高血压中维持血压的作用。尽管两种拮抗剂均能完全抑制外源性VP引起的升压反应，但注射20微克/千克的dPTyr（Me）AVP或10微克/千克的d（CH2）5Tyr（Me）AVP均未能改变平均动脉压或心率。这些结果表明，在这种类型的实验性高血压中，VP不作为升压激素参与高血压的维持。
