严重肥胖代谢和减重手术患者胆道疾病的管理:国际专家调查。
The Management of Biliary Disease in Patients with Severe Obesity Undergoing Metabolic and Bariatric Surgery-An International Expert Survey.
机构信息
Division of Minimally Invasive and Bariatric Surgery, Department of Surgery, Hazrat-E Fatemeh Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
出版信息
Obes Surg. 2024 Apr;34(4):1086-1096. doi: 10.1007/s11695-024-07101-y. Epub 2024 Feb 24.
OBJECTIVE
This study aimed to survey international experts in metabolic and bariatric surgery (MBS) to improve and consolidate the management of biliary disease in patients with severe obesity undergoing MBS.
BACKGROUND
Obesity and rapid weight loss after MBS are risk factors for the development of gallstones. Complications, such as cholecystitis, acute cholangitis, and biliary pancreatitis, are potentially life-threatening, and no guidelines for the proper management of gallstone disease exist.
METHODS
An international scientific team designed an online confidential questionnaire with 26 multiple-choice questions. The survey was answered by 86 invited experts (from 38 different countries), who participated from August 1, 2023, to September 9, 2023.
RESULTS
Two-thirds of experts (67.4%) perform concomitant cholecystectomy in symptomatic gallstones during MBS. Half of experts (50%) would wait 6-12 weeks between both surgeries with an interval approach. Approximately 57% of the experts prescribe ursodeoxycholic acid (UDCA) prophylactically after MBS, and most recommend a 6-month course. More than the half of the experts (59.3%/53.5%) preferred laparoscopic assisted transgastric ERCP as the approach for treating CBD stones in patients who previously had RYGB/OAGB.
CONCLUSION
Concomitant cholecystectomy is preferred by the experts, although evidence in the literature reports an increased complication rate. Prophylactic UDCA should be recommended to every MBS patient, even though the current survey demonstrated that not all experts are recommending it. The preferred approach for treating common bile duct stones is a laparoscopic assisted transgastric ERCP after gastric bypass. The conflicting responses will need more scientific work and clarity in the future.
目的
本研究旨在调查代谢和减重外科(MBS)领域的国际专家,以改善和巩固接受 MBS 的重度肥胖患者的胆道疾病管理。
背景
MBS 后肥胖和体重快速下降是胆囊结石发展的危险因素。胆囊炎、急性胆管炎和胆源性胰腺炎等并发症可能危及生命,目前尚无针对胆囊疾病适当管理的指南。
方法
一个国际科学团队设计了一个包含 26 个多项选择题的在线保密问卷。该调查由 86 名受邀专家(来自 38 个不同国家)于 2023 年 8 月 1 日至 9 月 9 日期间作答。
结果
三分之二的专家(67.4%)在 MBS 时对有症状的胆囊结石行同期胆囊切除术。一半的专家(50%)会在两次手术之间间隔 6-12 周,采用间隔方法。大约 57%的专家在 MBS 后预防性开熊去氧胆酸(UDCA),且大多数推荐疗程为 6 个月。超过一半的专家(59.3%/53.5%)首选腹腔镜辅助经胃 ERCP 作为治疗既往接受过 RYGB/OAGB 患者 CBD 结石的方法。
结论
专家们倾向于同期行胆囊切除术,尽管文献中的证据报告其并发症发生率增加。应该向每位接受 MBS 的患者推荐预防性 UDCA,尽管目前的调查显示并非所有专家都推荐使用。治疗胆总管结石的首选方法是胃旁路术后腹腔镜辅助经胃 ERCP。未来需要更多的科学研究和明晰性来解决这些有争议的问题。