Department of Otolaryngology-Head and Neck Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio, U.S.A.
Laryngoscope. 2024 Jul;134(7):3226-3229. doi: 10.1002/lary.31368. Epub 2024 Feb 24.
The primary objective was to examine the intersurgical interval (ISI) of recurrent respiratory papillomatosis (RRP) in patients older than 45 years before and after a Gardasil vaccination series.
We conducted a retrospective chart review of adult patients >45 years of age diagnosed with RRP from 2012 to 2022. Patients were excluded if they did not receive at least two doses of the Gardasil vaccine series or if they underwent two or fewer surgeries during the study period.
Thirteen patients met the inclusion criteria, 11 males and two females. The age at initial diagnosis ranged from 46 to 80 years, with a mean of 59 years. There was a significant increase in the average ISI, from 126 ± 87 days pre-vaccination compared to 494 ± 588 days post-vaccination (p < 0.01). The average number of surgeries per patient was 6.8 ± 2.4 over an average follow-up of 49.7 ± 30.3 months.
Adjuvant Gardasil use in RRP patients older than 45 years significantly increases the ISI. Current CDC recommendations include only patients ages 9 to 45, but this study provides evidence that RRP patients outside this age range may benefit from adjuvant HPV vaccination.
4 Laryngoscope, 134:3226-3229, 2024.
本研究旨在探讨 HPV 疫苗接种前后，45 岁以上复发性呼吸道乳头瘤病（RRP）患者的手术间隔时间（ISI）。
我们对 2012 年至 2022 年期间诊断为 RRP 的 45 岁以上成年患者进行了回顾性图表审查。如果患者未接受至少两剂 Gardasil 疫苗系列接种，或在研究期间接受了两次或更少的手术，则将其排除在外。
共有 13 名患者符合纳入标准，其中 11 名男性，2 名女性。首次诊断的年龄范围为 46 岁至 80 岁，平均年龄为 59 岁。与接种疫苗前的平均 ISI（126±87 天）相比，接种疫苗后的平均 ISI（494±588 天）显著增加（p<0.01）。每位患者的平均手术次数为 6.8±2.4 次，平均随访时间为 49.7±30.3 个月。
45 岁以上 RRP 患者使用辅助性 Gardasil 疫苗可显著延长 ISI。目前 CDC 的建议仅包括 9 至 45 岁的患者，但本研究提供了证据表明，该年龄范围之外的 RRP 患者可能受益于辅助性 HPV 疫苗接种。
4 Laryngoscope, 134:3226-3229, 2024.
