Poulain D A, Tasker J G
J Endocrinol. 1985 Oct;107(1):89-96. doi: 10.1677/joe.0.1070089.
In urethane-anaesthetized lactating rats, intramammary pressure occasionally displayed recurrent variations or oscillations having a slow rise time, low amplitude, long duration and a periodicity of 1-4 min. These oscillations differed from changes in intramammary pressure characteristic of reflex milk ejections induced by suckling, and were also observed in unsuckled rats. They were suppressed by lesions of the pituitary stalk or by stimulating the septum, a structure that inhibits the activity of the magnocellular system. They could be induced by long-term low frequency stimulation of the pituitary stalk, lesions of the septum or long-term infusions of oxytocin at a low rate of 0.05-0.3 mu./min. We suggest that the recurrent oscillations in intramammary pressure constitute a particular mode of response of the mammary gland to a tonic release of oxytocin resulting from a moderate but sustained increase in the basal level of electrical activity of the oxytocin-secreting neurones.
在氨基甲酸乙酯麻醉的泌乳大鼠中，乳腺内压偶尔会出现反复的变化或振荡，其上升时间缓慢、幅度低、持续时间长且周期为1 - 4分钟。这些振荡不同于因哺乳引起的反射性乳汁排出所特有的乳腺内压变化，在未哺乳的大鼠中也观察到了。垂体柄损伤或刺激隔膜（一种抑制大细胞系统活动的结构）可抑制这些振荡。长期低频刺激垂体柄、隔膜损伤或以0.05 - 0.3微单位/分钟的低速率长期输注催产素可诱发这些振荡。我们认为，乳腺内压的反复振荡构成了乳腺对催产素分泌神经元基础电活动水平适度但持续增加导致的催产素持续性释放的一种特殊反应模式。
