Department of Translational Medicine - Human Immunology, Lund University, J Waldenströms gata 35, Malmö, Sweden; Department of Clinical Immunology and Transfusion Medicine, Sahlgrenska University Hospital, Region Västra Götaland, Gothenburg, Sweden.
Peter Gorer Department of Immunobiology, King's College London, Guy's Hospital Campus, St Thomas' Street, London SE1 9RT, UK.
Trends Immunol. 2024 Mar;45(3):211-223. doi: 10.1016/j.it.2024.01.006. Epub 2024 Feb 23.
The diverse gut microbiota, which is associated with mucosal health and general wellbeing, maintains gut-associated lymphoid tissues (GALT) in a chronically activated state, including sustainment of germinal centers in a context of high antigenic load. This influences the rules for B cell engagement with antigen and the potential consequences. Recent data have highlighted differences between GALT and other lymphoid tissues. For example, GALT propagates IgA responses against glycans that show signs of having been generated in germinal centers. Other findings suggest that humans are among those species where GALT supports the diversification, propagation, and possibly selection of systemic B cells. Here, we review novel findings that identify GALT as distinctive, and able to support these processes.
肠道微生物群的多样性与黏膜健康和整体健康有关，使肠道相关淋巴组织 (GALT) 处于慢性激活状态，包括在高抗原负荷的情况下维持生发中心。这影响了 B 细胞与抗原结合的规则和潜在的后果。最近的数据强调了 GALT 与其他淋巴组织之间的差异。例如，GALT 对表现出生发中心生成迹象的聚糖产生 IgA 反应。其他研究结果表明，人类是支持 GALT 支持系统 B 细胞多样化、传播和可能选择的物种之一。在这里，我们回顾了一些新的发现，这些发现确定了 GALT 的独特性，并能够支持这些过程。
