Giri Ashwath Keshav, Subramanian Poorvi, Periyasamy Loganayaki, Aravindan Sivaroopan, Aravindan Natarajan
Department of Physiological Science, College of Veterinary Medicine, Oklahoma State University, Stillwater, OK 74078, USA.
Cells. 2025 Aug 7;14(15):1218. doi: 10.3390/cells14151218.
The composition of the gut and/or tumor microbiome has been intricately involved in the onset of carcinogenesis, tumor progression, therapy response, and patient outcomes in diverse solid cancers. The microbiome type, composition, and their metabolome have been functionally implicated in the multifarious cellular processes, transformation, proliferation, tumor immune evasion, cellular migration, etc. Despite such compelling evidence on the role of microbiome interactions in cancer, the realization of their role in neuroblastoma (NB), the deadly extracranial tumor in infants is few and fragmentary. This review comprehends the composition, diversity, and significance of microbiota in human health. Further, this review discusses the microbiota composition, their mode of action, and their signaling flow through and cellular processes in diverse cancers including NB. Precisely, this study for the first time has realized the functional relevance and clinical significance of the gut and tumor microbiome for NB. Interestingly, large cohort clinical and preclinical in vivo models of NB realized the following: gut microbiota predicts the risk for NB; postnatal (and or not maternal transmission) microbiome rearrangements; gut microbial effect on NB pathogenesis; tumor-altering gut microbial composition; microbial composition predicts treatment outcomes in NB; prebiotic remedies for stabilizing NB-associated microbial rearrangements; microbial composition in tumor-infiltrating microbiota predicts NB outcomes.
肠道和/或肿瘤微生物组的组成与多种实体癌的致癌作用、肿瘤进展、治疗反应及患者预后密切相关。微生物组的类型、组成及其代谢组在多种细胞过程、转化、增殖、肿瘤免疫逃逸、细胞迁移等方面具有功能相关性。尽管有确凿证据表明微生物组相互作用在癌症中发挥作用，但它们在神经母细胞瘤（NB）（婴儿致命的颅外肿瘤）中的作用却鲜为人知且支离破碎。本综述阐述了微生物群在人类健康中的组成、多样性及重要性。此外，本综述还讨论了微生物群的组成、作用方式以及它们在包括NB在内的多种癌症中的信号传导途径和细胞过程。确切地说，本研究首次认识到肠道和肿瘤微生物组对NB的功能相关性及临床意义。有趣的是，NB的大型队列临床和临床前体内模型揭示了以下内容：肠道微生物群可预测NB风险；出生后（及或非母体传播）微生物组重排；肠道微生物对NB发病机制的影响；肿瘤改变肠道微生物组成；微生物组成可预测NB的治疗结果；用于稳定NB相关微生物重排的益生元疗法；肿瘤浸润微生物群中的微生物组成可预测NB结果。
