Forestier F, Daffos F, Rainaut M, Solé Y, Amiral J
Thromb Haemost. 1985 Jun 24;53(3):401-3.
The vitamin K dependent coagulation factor activities were measured in 63 normal human fetuses from 19 to 28 weeks of pregnancy. These activities were included between 9 to 28 percent of normal adult levels. Prothrombin antigen, factor IX antigen and protein C were also measured. There is a good correlation between prothrombin procoagulant activity and antigenicity, suggesting that low level of these vitamin K dependent proteins in fetuses is probably a consequence of liver immaturity.
对63例妊娠19至28周的正常人类胎儿进行了维生素K依赖凝血因子活性测定。这些活性为正常成人水平的9%至28%。还测定了凝血酶原抗原、因子IX抗原和蛋白C。凝血酶原促凝活性与抗原性之间存在良好相关性，提示胎儿中这些维生素K依赖蛋白水平较低可能是肝脏不成熟的结果。
