From the Department of Ophthalmology (M.K., H.S., M.A.), Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
From the Department of Ophthalmology (M.K., H.S., M.A.), Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Am J Ophthalmol. 2024 Jul;263:99-108. doi: 10.1016/j.ajo.2024.02.017. Epub 2024 Feb 23.
To explore the effects of deep optic nerve head (ONH) structures on Bruch's membrane opening (BMO)-minimum rim width (MRW) and peripapillary retinal nerve fiber layer thickness (pRNFLT) in healthy eyes.
Prospective cross-sectional study.
Two hundred five healthy eyes of 141 subjects (mean ± standard deviation of age and axial length (AXL): 46.9 ± 10.0 years and 24.79 ± 1.15 mm) were enrolled. Best fit multivariable linear mixed models identified factors associated with BMO-MRW and pRNFLT. Explanatory variables included age, gender, AXL, BMO and anterior scleral canal opening (ASCO) area and ovality, magnitude of BMO and ASCO shift, peripapillary choroidal thickness, lamina cribrosa (LC) parameters, prelaminar thickness, and peripapillary scleral (PPS) angle.
Thinner BMO-MRW was associated with older age, smaller ASCO/BMO offset magnitude, larger BMO area, thinner prelaminar thickness, deeper LC, and thinner pRNFLT (P = .011, <.001, .004, <.001, <.001, <.001 respectively). Thinner pRNFLT was associated with shorter AXL, smaller ASCO area, a more posteriorly bowed PPS, shallower LC and thinner BMO-MRW. (P = .030, .002, .035, .012, <.001 respectively) CONCLUSIONS: BMO-MRW and pRNFLT were influenced by several deep ONH structures such as BMO and ASCO position shift, BMO or ASCO area, prelaminar thickness, PPS bowing and LC depth in addition to patient characteristics such as age and AXL. The degree and/or direction of associations varied between deep ONH structures and BMO-MRW or pRNFLT. Despite both BMO-MRW and pRNFLT being surrogate parameters for RGC loss, a complex relationship with ONH deep-layer morphology was indicated.
探讨健康眼中视神经头（ONH）深部结构对Bruch 膜开口（BMO）-最小边缘宽度（MRW）和视盘周围视网膜神经纤维层厚度（pRNFLT）的影响。
前瞻性横断面研究。
共纳入 141 名受试者的 205 只健康眼（平均年龄和眼轴（AXL）标准差：46.9±10.0 岁和 24.79±1.15mm）。采用最佳拟合多变量线性混合模型确定与 BMO-MRW 和 pRNFLT 相关的因素。解释变量包括年龄、性别、AXL、BMO 和前巩膜管开口（ASCO）面积和椭圆形、BMO 和 ASCO 移位幅度、视盘周围脉络膜厚度、筛板（LC）参数、视盘前厚度和视盘周围巩膜（PPS）角。
BMO-MRW 变薄与年龄较大、ASCO/BMO 偏移幅度较小、BMO 面积较大、视盘前厚度较薄、LC 较深和 pRNFLT 较薄有关（P=0.011，<0.001，0.004，<0.001，<0.001，<0.001）。pRNFLT 变薄与 AXL 较短、ASCO 面积较小、后凸 PPS、较浅的 LC 和较薄的 BMO-MRW 有关（P=0.030，0.002，0.035，0.012，<0.001）。
除了患者特征（如年龄和 AXL）外，BMO-MRW 和 pRNFLT 还受到 ONH 深部结构（如 BMO 和 ASCO 位置移位、BMO 或 ASCO 面积、视盘前厚度、PPS 弯曲和 LC 深度）的影响。深部 ONH 结构与 BMO-MRW 或 pRNFLT 之间的关联程度和方向各不相同。尽管 BMO-MRW 和 pRNFLT 都是 RGC 损失的替代参数，但它们与 ONH 深层形态之间存在复杂的关系。
