COVID-19 危重症患者遗传变异的关联分析及在中国人群中的验证。
Association analysis of genetic variants in critical patients with COVID-19 and validation in a Chinese population.
机构信息
Center for Natural Products Research, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, 610213, China; Sichuan Provincial Key Laboratory for Human Disease Gene Study, Center for Medical Genetics, Department of Laboratory Medicine, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, China; Research Unit for Blindness Prevention of Chinese Academy of Medical Sciences (2019RU026), Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, China; University of Chinese Academy of Sciences, Beijing, 100049, China.
Sichuan Provincial Key Laboratory for Human Disease Gene Study, Center for Medical Genetics, Department of Laboratory Medicine, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, China; Research Unit for Blindness Prevention of Chinese Academy of Medical Sciences (2019RU026), Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, China.
出版信息
Virol Sin. 2024 Apr;39(2):347-350. doi: 10.1016/j.virs.2024.02.004. Epub 2024 Feb 23.
• Single-nucleotide polymorphisms in critical patients with COVID-19 conducted worldwide are validated in Chinese population. • Variants in and near and show the strongest associated signals in Chinese population. • Rs1886814 in is correlated with COVID-19 severity in Chinese and other populations.
• 在全球范围内对 COVID-19 重症患者进行的单核苷酸多态性研究在中国人群中得到了验证。 • 及附近 和 中的变异在中国人群中显示出最强的关联信号。 • 中的 Rs1886814 与中国人群和其他人群的 COVID-19 严重程度相关。
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