Pacold I, Ackerman L, Johnson B, Reid R W, Freeman M L, Loeb H S, Kaplan E
Am Heart J. 1985 Oct;110(4):836-40. doi: 10.1016/0002-8703(85)90466-1.
The effects of acute hypertriglyceridemia and of high levels of free fatty acids on the left ventricular ejection fraction were studied by radionuclide ventriculography in 20 subjects with and without coronary artery disease. An infusion of approximately 125 ml of a 20% fat emulsion over 25 minutes resulted in an increase of plasma triglycerides to the mean of 820 mg/dl and a fall of the left ventricular ejection fraction from the baseline mean of 62% to 58% (p less than 0.05). Ninety minutes after the intravenous administration of 5000 units of heparin, plasma free fatty acids rose to the mean of 4.6 mmol/L and the mean left ventricular ejection fraction increased to 69% (p less than 0.001). The observed changes in blood lipids were not associated with clinical or ECG evidence of myocardial ischemia. We conclude that acute hypertriglyceridemia causes slight depression of left ventricular performance, while high levels of free fatty acids augment it. However, neither hypertriglyceridemia per se nor its rapid conversion to free fatty acids are likely to cause angina in stable patients with coronary artery disease.
通过放射性核素心室造影术，对20名有或无冠状动脉疾病的受试者研究了急性高甘油三酯血症和高水平游离脂肪酸对左心室射血分数的影响。在25分钟内输注约125毫升20%的脂肪乳剂，导致血浆甘油三酯增加至平均820毫克/分升，左心室射血分数从基线平均值62%降至58%（p<0.05）。静脉注射5000单位肝素90分钟后，血浆游离脂肪酸升至平均4.6毫摩尔/升，左心室射血分数平均值增至69%（p<0.001）。观察到的血脂变化与心肌缺血的临床或心电图证据无关。我们得出结论，急性高甘油三酯血症会导致左心室功能轻微下降，而高水平游离脂肪酸则会增强左心室功能。然而，无论是高甘油三酯血症本身还是其快速转化为游离脂肪酸，都不太可能在稳定的冠状动脉疾病患者中引发心绞痛。
