Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Tan Tock Seng Hospital, National Healthcare Group, Singapore.
Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Ophthalmol Glaucoma. 2024 Jul-Aug;7(4):359-371. doi: 10.1016/j.ogla.2024.02.008. Epub 2024 Feb 23.
To investigate differences in peripapillary choroidal thickness (PPCT) between primary open-angle glaucoma (POAG), normal tension glaucoma (NTG), and healthy eyes, additionally comparing differences between POAG and NTG eyes.
Peripapillary choroidal thickness is a well-established OCT parameter in eyes with glaucoma and other ocular pathologies. The relationship between PPCT and glaucoma, if better understood, may facilitate the development of PPCT as a potential diagnostic and monitoring metric for glaucoma. In particular, there has yet to be a synthesis that directly compares PPCT between POAG eyes and NTG eyes.
A comprehensive literature search was performed on PubMed, EMBASE, and Cochrane Library, identifying studies from inception to December 2022. We included studies that measured PPCT using OCT in POAG, NTG, and healthy eyes. Mean difference (MD) among groups was calculated. Statistical analysis was performed using R version 4.2.0. Risk of bias of included studies was assessed using the Newcastle Ottawa Scale (NOS).
Eighteen studies were included in this meta-analysis, with a pooled total of 935 healthy control eyes, 446 NTG eyes, and 934 POAG eyes. There was a significant reduction of PPCT in POAG eyes compared with healthy eyes [MD = -16.32; 95% confidence interval (CI) (-27.55 to -5.09)]. Reduction in PPCT was also significant in NTG eyes compared with healthy eyes [MD = -34.96; 95% CI (-49.97 to -19.95)]. NTG eyes had significantly reduced PPCT compared with POAG eyes [MD = -26.64; 95% CI (-49.00 to -4.28)].
Glaucomatous eyes appear to have significantly reduced PPCT compared with normal healthy eyes. In addition, PPCT in NTG eyes appear significantly thinner compared with that in POAG eyes.
FINANCIAL DISCLOSURE(S): Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
探讨原发性开角型青光眼（POAG）、正常眼压型青光眼（NTG）和健康眼之间的视盘周围脉络膜厚度（PPCT）差异，并比较 POAG 和 NTG 眼之间的差异。
视盘周围脉络膜厚度是青光眼和其他眼部疾病中一种成熟的 OCT 参数。如果更好地理解 PPCT 与青光眼之间的关系，可能有助于将 PPCT 作为青光眼的潜在诊断和监测指标。特别是，目前还没有直接比较 POAG 眼和 NTG 眼之间的 PPCT 的综合研究。
对 PubMed、EMBASE 和 Cochrane Library 进行全面文献检索，从建库至 2022 年 12 月纳入研究。纳入使用 OCT 测量 POAG、NTG 和健康眼的 PPCT 的研究。计算组间平均差异（MD）。使用 R 版本 4.2.0 进行统计分析。使用纽卡斯尔-渥太华量表（NOS）评估纳入研究的偏倚风险。
本荟萃分析纳入了 18 项研究，共有 935 只健康对照眼、446 只 NTG 眼和 934 只 POAG 眼。POAG 眼的 PPCT 明显低于健康眼[MD=-16.32；95%置信区间（CI）（-27.55 至-5.09）]。NTG 眼的 PPCT 也明显低于健康眼[MD=-34.96；95%CI（-49.97 至-19.95）]。与 POAG 眼相比，NTG 眼的 PPCT 明显减少[MD=-26.64；95%CI（-49.00 至-4.28）]。
与正常健康眼相比，青光眼眼的 PPCT 似乎明显降低。此外，NTG 眼的 PPCT 明显比 POAG 眼薄。
本文末尾的脚注和披露中可能会发现专有或商业披露。
