Coupland S G, McLeod D R, Wesenberg R L, Lowry R B
Am J Med Genet. 1985 Oct;22(2):375-81. doi: 10.1002/ajmg.1320220222.
The metacarpophalangeal profile (MCP) pattern has been proven useful in describing individuals with genetic and nongenetic syndromes. However, the measurement of the 19 bone lengths is a tedious procedure requiring use of hand vernier calipers, detailed normative data to be looked up in extensive tables, hand calculator, and manual graphing techniques. Presently there are no reports of microcomputer-automated systems for the accurate measurement, recording, analysis, and graphing of MCP profiles. We describe a computer-automated metacarpophalangeal profile system (CAMPS) that will assist in the derivation of the MCP profile. This program allows the user to select different program routines that perform the functions necessary for MCP profile construction. The "data acquisition module" (DAM) assists in bone length measurement from contact prints of hand radiographs and stores the 19 measurements on a floppy disk. The "standardization analysis module" (SAM) then compares the 19 measurements to age- and sex-matched normal data and converts the raw data to z-score values. The "Pearson product-moment correlation module" (PPM) generates a correlation coefficient describing the degree of similarity between the two hands measured and graphically illustrates the resulting scatterplot. The "MCP plotting module" (MCPM) provides a graphic plot of the 19 bones in either transverse rows or phalangeal rays on a dot-matrix printer or X-Y plotter.
掌指骨轮廓(MCP)模式已被证明在描述患有遗传和非遗传综合征的个体方面很有用。然而,测量19根骨骼的长度是一个繁琐的过程,需要使用手动游标卡尺、在大量表格中查找详细的规范数据、手持计算器以及手动绘图技术。目前尚无关于用于MCP轮廓精确测量、记录、分析和绘图的微机自动化系统的报道。我们描述了一种计算机自动化掌指骨轮廓系统(CAMPS),它将有助于推导MCP轮廓。该程序允许用户选择不同的程序例程,这些例程执行构建MCP轮廓所需的功能。“数据采集模块”(DAM)通过手部X线片的接触印片辅助测量骨骼长度,并将这19项测量值存储在软盘上。“标准化分析模块”(SAM)然后将这19项测量值与年龄和性别匹配的正常数据进行比较,并将原始数据转换为z分数值。“皮尔逊积矩相关模块”(PPM)生成一个相关系数,描述所测量的两只手之间的相似程度,并以图形方式显示所得的散点图。“MCP绘图模块”(MCPM)在点阵打印机或X - Y绘图仪上以横向行或指骨射线的形式提供19根骨骼的图形绘制。