• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

IgA 肾病患者接种 COVID-19 疫苗后出现大量血尿是否与足细胞病有关？

Is Podocytopathy Associated with Gross Hematuria after COVID-19 Vaccination in Patients with Immunoglobulin A Nephropathy?

机构信息

Department of Nephrology and Rheumatology, Toranomon Hospital Kajigaya, Japan.

Department of Nephrology, Saga University Internal Medicine, Japan.

出版信息

Intern Med. 2024 Oct 15;63(20):2821-2825. doi: 10.2169/internalmedicine.3247-23. Epub 2024 Feb 26.

DOI:10.2169/internalmedicine.3247-23
PMID:38403757
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11557193/
Abstract

We experienced three cases of a fever and subsequent severe, prolonged gross hematuria after COVID-19 vaccination. A kidney biopsy revealed immunoglobulin A (IgA) nephropathy, and electron microscopy showed two types of podocytopathy (podocyte damage): loss of foot processes from the glomerular basement membrane and foot process effacement. Mesangial interposition was also present in cases 1 and 3 but not in case 2. Podocytopathy is known to be a cause of proteinuria; however, the reactions to COVID-19 vaccination described here suggest that it may also be related to hematuria in IgA nephropathy.

摘要

我们遇到了三例接种 COVID-19 疫苗后发热和随后严重、持续的肉眼血尿。肾活检显示免疫球蛋白 A（IgA）肾病，电子显微镜显示两种足细胞病（足细胞损伤）：肾小球基底膜的足突从基底膜脱落和足突消失。系膜插入也存在于病例 1 和 3 中，但在病例 2 中不存在。足细胞病已知是蛋白尿的原因；然而，这里描述的 COVID-19 疫苗接种反应表明，它也可能与 IgA 肾病的血尿有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b0b/11557193/4837bec85e93/1349-7235-63-2821-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b0b/11557193/a4c979c583fc/1349-7235-63-2821-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b0b/11557193/2c750368e31e/1349-7235-63-2821-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b0b/11557193/4837bec85e93/1349-7235-63-2821-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b0b/11557193/a4c979c583fc/1349-7235-63-2821-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b0b/11557193/2c750368e31e/1349-7235-63-2821-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b0b/11557193/4837bec85e93/1349-7235-63-2821-g003.jpg

相似文献

1
Is Podocytopathy Associated with Gross Hematuria after COVID-19 Vaccination in Patients with Immunoglobulin A Nephropathy?IgA 肾病患者接种 COVID-19 疫苗后出现大量血尿是否与足细胞病有关？
Intern Med. 2024 Oct 15;63(20):2821-2825. doi: 10.2169/internalmedicine.3247-23. Epub 2024 Feb 26.
2
Adverse reactions and effects on renal function of COVID-19 vaccines in patients with IgA nephropathy.IgA 肾病患者 COVID-19 疫苗的不良反应及对肾功能的影响。
Clin Exp Nephrol. 2024 Nov;28(11):1168-1177. doi: 10.1007/s10157-024-02521-7. Epub 2024 Jun 15.
3
Sibling cases of gross hematuria and newly diagnosed IgA nephropathy following SARS-CoV-2 vaccination.SARS-CoV-2 疫苗接种后出现肉眼血尿和新诊断的 IgA 肾病的同胞病例。
BMC Nephrol. 2022 Jun 21;23(1):216. doi: 10.1186/s12882-022-02843-2.
4
Gross hematuria can be an impact of severe acute respiratory syndrome coronavirus 2 vaccination on immunoglobulin A nephropathy: a case report.肉眼血尿可能是严重急性呼吸综合征冠状病毒 2 疫苗接种对 IgA 肾病的影响：一例报告。
J Med Case Rep. 2022 Jul 11;16(1):273. doi: 10.1186/s13256-022-03514-4.
5
Secondary immunoglobulin A nephropathy with gross hematuria leading to rapidly progressive glomerulonephritis following severe acute respiratory syndrome coronavirus 2 vaccination: a case report.接种严重急性呼吸综合征冠状病毒 2 疫苗后导致巨量血尿和快速进行性肾小球肾炎的继发性免疫球蛋白 A 肾病：一例报告。
BMC Nephrol. 2023 Aug 8;24(1):232. doi: 10.1186/s12882-023-03287-y.
6
Acute kidney injury with gross hematuria and IgA nephropathy after COVID-19 vaccination.新冠疫苗接种后出现伴有肉眼血尿的急性肾损伤和IgA肾病。
Kidney Int. 2021 Oct;100(4):944-945. doi: 10.1016/j.kint.2021.07.020. Epub 2021 Aug 3.
7
Gross hematuria following SARS-CoV-2 vaccination in patients with IgA nephropathy.IgA肾病患者接种新型冠状病毒2疫苗后出现肉眼血尿。
Kidney Int. 2021 Aug;100(2):466-468. doi: 10.1016/j.kint.2021.05.022. Epub 2021 Jun 1.
8
IgA Nephropathy with Gross Hematuria Following COVID-19 mRNA Vaccination.接种 COVID-19 mRNA 疫苗后出现 IgA 肾病伴肉眼血尿。
Intern Med. 2022 Apr 1;61(7):1033-1037. doi: 10.2169/internalmedicine.8787-21. Epub 2022 Feb 1.
9
Comparison of renal histopathology in three patients with gross hematuria after SARS-CoV-2 vaccination.三例接种 SARS-CoV-2 疫苗后出现肉眼血尿患者的肾组织病理学比较。
CEN Case Rep. 2023 May;12(2):176-183. doi: 10.1007/s13730-022-00743-w. Epub 2022 Oct 11.
10
IgA nephropathy with glomerular capillary IgA deposition following SARS-CoV-2 mRNA vaccination: a report of three cases.接种 SARS-CoV-2 mRNA 疫苗后出现的 IgA 肾病伴肾小球毛细血管 IgA 沉积：三例报告。
CEN Case Rep. 2022 Nov;11(4):499-505. doi: 10.1007/s13730-022-00707-0. Epub 2022 May 13.

本文引用的文献

1
First Diagnosis of Immunoglobulin A Nephropathy Following SARS-CoV-2 mRNA Vaccination in Japan.日本首例接种新型冠状病毒mRNA疫苗后诊断为免疫球蛋白A肾病
Kidney Int Rep. 2023 Jan;8(1):179-182. doi: 10.1016/j.ekir.2022.10.012. Epub 2022 Oct 19.
2
Sibling cases of gross hematuria and newly diagnosed IgA nephropathy following SARS-CoV-2 vaccination.SARS-CoV-2 疫苗接种后出现肉眼血尿和新诊断的 IgA 肾病的同胞病例。
BMC Nephrol. 2022 Jun 21;23(1):216. doi: 10.1186/s12882-022-02843-2.
3
COVID-19 Vaccination and Glomerulonephritis.2019冠状病毒病疫苗接种与肾小球肾炎
Kidney Int Rep. 2021 Dec;6(12):2969-2978. doi: 10.1016/j.ekir.2021.09.008. Epub 2021 Oct 6.
4
Podocytopathy in the mesangial proliferative immunoglobulin A nephropathy: new insights into the mechanisms of damage and progression.足细胞病变在系膜增生性 IgA 肾病中的作用：对损伤和进展机制的新认识。
Nephrol Dial Transplant. 2019 Aug 1;34(8):1280-1285. doi: 10.1093/ndt/gfy413.
5
Immunosuppressive Treatment in Children With IgA Nephropathy and the Clinical Value of Podocytopathic Features.IgA肾病患儿的免疫抑制治疗及足细胞病变特征的临床价值
Kidney Int Rep. 2018 Mar 29;3(4):916-925. doi: 10.1016/j.ekir.2018.03.013. eCollection 2018 Jul.
6
Understanding podocytopathy and its relevance to clinical nephrology.了解足细胞病及其与临床肾脏病学的相关性。
Indian J Nephrol. 2015 Jan-Feb;25(1):1-7. doi: 10.4103/0971-4065.134531.
7
IgA nephropathy with minimal change disease.IgA 肾病伴微小病变病。
Clin J Am Soc Nephrol. 2014 Jun 6;9(6):1033-9. doi: 10.2215/CJN.11951113. Epub 2014 Apr 10.
8
Regression of IgA nephropathy: a repeat biopsy study.IgA肾病的消退：一项重复肾活检研究。
Am J Kidney Dis. 2002 Mar;39(3):493-502. doi: 10.1053/ajkd.2002.31399.