Shepherd R K, Murray M T, Houghton M E, Clark G M
Biomaterials. 1985 Jul;6(4):237-42. doi: 10.1016/0142-9612(85)90019-5.
Platinum electrodes were examined for evidence of corrosion using a scanning electron microscope (SEM). In vivo electrodes, stimulated using charge-balanced biphasic pulses for periods of up to 2000 h at charge densities of 0.18-0.32 microC mm-2 geom. per phase, were compared with in vitro electrodes stimulated in inorganic saline using similar stimulus parameters, and with in vivo control electrodes. The in vitro stimulated electrodes showed evidence of platinum corrosion at high charge density and aggregate charge injection. Significantly, the in vivo stimulated electrodes showed no evidence of stimulus induced corrosion. Indeed, their surfaces were similar to the in vivo control electrodes. In vitro electrochemical studies have demonstrated that proteins play a significant role in the inhibition of platinum dissolution: the present study has demonstrated an inhibitory effect in vivo. This may be due to the presence of proteins.
使用扫描电子显微镜（SEM）检查铂电极是否有腐蚀迹象。将体内电极与体外电极及体内对照电极进行比较，体内电极以0.18 - 0.32微库仑/平方毫米几何面积/相的电荷密度，使用电荷平衡双相脉冲刺激长达2000小时，体外电极在无机盐溶液中使用类似刺激参数进行刺激。体外刺激的电极在高电荷密度和总电荷注入时显示出铂腐蚀迹象。值得注意的是，体内刺激的电极没有显示出刺激诱导腐蚀的迹象。实际上，它们的表面与体内对照电极相似。体外电化学研究表明蛋白质在抑制铂溶解中起重要作用：本研究在体内也证明了这种抑制作用。这可能是由于蛋白质的存在。
