Department of Anesthesiology and Pain Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Department of Surgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Head Neck. 2024 Aug;46(8):2068-2075. doi: 10.1002/hed.27701. Epub 2024 Feb 25.
Multiple medications are more effective than single agents for postoperative pain management. We investigated the analgesic effects of an intravenous combination of acetaminophen and ibuprofen immediately after thyroidectomy.
In this double-blind clinical trial, 62 patients who underwent thyroidectomies were randomized to either the treatment (1000 mg acetaminophen, 300 mg ibuprofen) or control (1000 mg acetaminophen) group. Postoperative pain intensity was assessed using the visual analog scale (VAS) 0, 15, and 30 min after recovery room admission. Opioid rescue consumption was also recorded.
The VAS scores were significantly lower in the treatment than in the control group 15 [3 (2-4.3) vs. 5 (3-6); p = 0.015] and 30 [3 (2-4.3) vs. 4 (3-5); p = 0.018] min after recovery room admission, as were the opioid rescue dose requirements (p = 0.033).
Combined intravenous acetaminophen and ibuprofen may be better than acetaminophen alone for immediately acute postoperative pain after thyroidectomy.
与单一药物相比，多种药物在术后疼痛管理方面更有效。我们研究了甲状腺切除术后立即静脉注射乙酰氨基酚和布洛芬联合用药的镇痛效果。
在这项双盲临床试验中，62 例行甲状腺切除术的患者被随机分为治疗（1000mg 对乙酰氨基酚，300mg 布洛芬）或对照组（1000mg 对乙酰氨基酚）。在恢复室入院后 0、15 和 30 分钟使用视觉模拟量表（VAS）评估术后疼痛强度。还记录了阿片类药物的解救消耗量。
治疗组在恢复室入院后 15 分钟[3（2-4.3）比 5（3-6）；p=0.015]和 30 分钟[3（2-4.3）比 4（3-5）；p=0.018]时的 VAS 评分明显低于对照组，阿片类药物解救剂量需求也较低（p=0.033）。
与单独使用对乙酰氨基酚相比，甲状腺切除术后立即使用静脉注射乙酰氨基酚和布洛芬联合用药可能更能缓解急性术后疼痛。
