Effects of isaxonine on skeletal muscle reinnervation in the rat: an electrophysiologic evaluation.
作者信息
Pecot-Dechavassine M, Mira J C
出版信息
Muscle Nerve. 1985 Feb;8(2):105-14. doi: 10.1002/mus.880080205.
PMID:3840570
Abstract
Electrophysiologic detection of the first signs of gastrocnemius muscle reinnervation shows that after a single localized freezing of the rat sciatic nerve, isaxonine does not significantly increase the rate of axonal regeneration. However, this drug does significantly enhance axonal sprouting, as it induces an increase of 50% in the number of muscle fibers with multiple innervation 10-30 days after freezing. After 30 days, the proportion of multiinnervated fibers decreases in both the control and isaxonine-treated rats, and the differences between them gradually disappear.
摘要
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引用本文的文献
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Influence of isaxonine on the target phenomenon, muscle fibre size and neuromuscular junction in the tenotomized and denervated gastrocnemius muscle of the rat.异克索宁对大鼠跟腱切断和去神经支配的腓肠肌中靶现象、肌纤维大小及神经肌肉接头的影响。
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