Abdellatif Mohammed Ar, Rabi Karam, Ghanem Ahmed T, Dawoud Ahmed, Bakri Izzeddin A
Department of Medicine, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, PSE.
Department of Neurosurgery, Palestinian Medical Complex, Ramallah, PSE.
Cureus. 2024 Jan 23;16(1):e52834. doi: 10.7759/cureus.52834. eCollection 2024 Jan.
Giant cell tumors (GCTs), typically benign, predominantly manifest in individuals aged 20-40, with the most common locations being the metaphysis or epiphysis of the femur or tibia. Infrequently, they may occur in the skull. Despite their benign nature, these tumors can exhibit aggressive behavior and have the potential to metastasize. In the case at hand, a 20-year-old female presented to the hospital with a progressively enlarging right frontal swelling over the preceding months. The patient reported intermittent headaches, alleviated by analgesics, and exhibited a normal neurological examination along with a Glasgow Coma Scale (GCS) score of 15 out of 15. Imaging revealed an expansive soft tissue mass in the right frontal bone involving both inner and outer tables. Surgical intervention was pursued through a right frontal incision followed by tumor excision. Histopathological examination of the specimen confirmed the presence of a GCT. The limited existing literature on this topic highlights the need for further research and insights into effective strategies. This case contributes to addressing this gap in knowledge, offering valuable information to enhance our understanding of the challenges associated with similar rare cases and improve patient outcomes.
骨巨细胞瘤(GCTs)通常为良性,主要发生于20至40岁的个体,最常见的部位是股骨或胫骨的干骺端或骨骺。罕见情况下,它们也可能发生在颅骨。尽管这些肿瘤本质上是良性的,但它们可能表现出侵袭性,并有可能发生转移。在本例中,一名20岁女性在过去几个月中因右侧额部肿胀逐渐增大而入院。患者报告有间歇性头痛,服用镇痛药后缓解,神经系统检查正常,格拉斯哥昏迷量表(GCS)评分为满分15分。影像学检查显示右侧额骨有一个膨胀性软组织肿块,累及内板和外板。通过右侧额部切口进行手术干预,随后切除肿瘤。标本的组织病理学检查证实为骨巨细胞瘤。关于这一主题的现有文献有限,凸显了进一步研究以及深入了解有效策略的必要性。本病例有助于填补这一知识空白,提供有价值的信息,以增进我们对类似罕见病例相关挑战的理解,并改善患者的治疗效果。