Department of Cardiology, Liaquat National Hospital and Medical College, Karachi, Pakistan.
Department of Pharmacy and Pharmaceutical Sciences, University of Karachi, Pakistan.
J Ayub Med Coll Abbottabad. 2023 Oct-Dec;35(4):612-615. doi: 10.55519/JAMC-04-12285.
One of the major causes of cardiovascular morbidity and mortality is heart failure. The study aims to assess the effect of heart rate on the incidence of rehospitalization in patients with heart failure and reduced ejection fraction.
It is a cross-sectional, analytical research conducted over six months, from June to December 2022, at the cardiology department of a tertiary care hospital. Patients who satisfied the modified Framingham heart failure criteria at admission and were discharged with an initial diagnosis of heart failure and those readmitted within 6 months or less of their discharge were included in the study. Pregnant women, patients diagnosed with cognitive impairment, and patients who had contraindications for taking any of the beta-blockers, angiotensin-converting enzyme inhibitor/angiotensin receptor blocker /angiotensin receptor -neprilysin inhibitor, Sodium-Glucose co-transport inhibitor, and mineralocorticoid inhibitors were excluded from the study.
A total of 77 patients were included in the study. At discharge, approximately 71 patients had a heart rate of less than 70 beats/min and had no readmissions whereas, 6 patients had a heart rate of greater than 70 beats/min with 5 patients requiring readmission in the following 6 months. This relationship was statistically significant with a p-value of 0.000.
According to the study, heart rate is a significant factor in the rehospitalization of individuals with heart failure and a low ejection fraction. At discharge, if the heart rate is not optimized then the rate of readmissions is increased.
心血管发病率和死亡率的主要原因之一是心力衰竭。本研究旨在评估心率对射血分数降低的心力衰竭患者再住院发生率的影响。
这是一项横断面分析研究，于 2022 年 6 月至 12 月在一家三级保健医院的心脏病科进行，为期 6 个月。符合入院时改良 Framingham 心力衰竭标准并以心力衰竭和初始诊断出院且在出院后 6 个月内再次入院的患者，以及在出院后 6 个月内再次入院的患者，均纳入研究。排除孕妇、诊断为认知障碍的患者，以及有服用任何β受体阻滞剂、血管紧张素转换酶抑制剂/血管紧张素受体阻滞剂/血管紧张素受体-脑啡肽酶抑制剂、钠-葡萄糖共转运蛋白抑制剂和盐皮质激素受体抑制剂禁忌证的患者。
共有 77 例患者纳入研究。出院时，大约 71 例患者的心率低于 70 次/分钟，且无再入院病例，而 6 例患者的心率大于 70 次/分钟，其中 5 例在接下来的 6 个月内需要再次入院。这种关系具有统计学意义，p 值为 0.000。
根据这项研究，心率是心力衰竭和射血分数降低患者再住院的一个重要因素。出院时，如果心率没有得到优化，那么再入院的几率就会增加。
