Army Medical College, National University of Medical Sciences Rawalpindi.
Combined Military Hospital Kharian.
J Ayub Med Coll Abbottabad. 2023 Oct-Dec;35(4):619-622. doi: 10.55519/JAMC-04-12357.
Bone Marrow examination is considered to be the most indispensable diagnostic tool for the evaluation of many neoplastic and non-neoplastic haematological disorders. After an initial assessment of suspicious cases on abnormal laboratory parameters along with the clinical presentation of the patient marrow examination is finally required for diagnosis as well as management of many haematological malignancies as it offers a clear cytological as well as histological picture of Bone Marrow aspirate and biopsy respectively. The Objective was to evaluate the significance of Bone Marrow examination in patients with abnormal haematological parameters.
A retrospective study conducted at the Pathology Department of Pak Emirates Military Hospital from (Jan-June 2022) On data from150 patients who were advised to undergo bone marrow examination due to abnormal lab parameters and peripheral smear findings after informed consent and approval from the ethics review committee, to find out the correlation of abnormal haematological parameters and aspirate findings which have led to a definitive diagnosis. Data comprising basic demographic variables (age, gender etc.), Abnormal Haematological Parameters (CBC), peripheral smear findings and Aspirate findings were analyzed using SPSS version 23.0.
Out of 150 studied participants with abnormal haematological parameters 24 (16%) were diagnosed on bone marrow examination as acute leukaemia / Hodgkin's and Non-Hodgkin's lymphoma respectively, 13 (9%) cases of aplastic anaemia and Autoimmune HaemolyticAnaemia, 33 (22%)cases of hypersplenism, CML and multiple myeloma. While 22 (15%) cases were diagnosed with BME as CKD and reactive changes. Moreover, 22(15%) cases were found to have Iron Deficiency anaemia respectively.
The study revealed that patients with abnormal haematological parameters should undergo bone marrow examination to ascertain the diagnosis for malignant as well as non-malignant conditions that could cause abnormal lab parameters.
骨髓检查被认为是评估许多肿瘤性和非肿瘤性血液病的最不可或缺的诊断工具。在对异常实验室参数和患者临床表现进行初步评估后，最终需要进行骨髓检查以诊断和管理许多血液恶性肿瘤，因为它分别提供了骨髓抽吸和活检的清晰细胞学和组织学图像。目的是评估骨髓检查在异常血液学参数患者中的意义。
在巴基斯坦阿联酋军事医院病理科进行的回顾性研究（2022 年 1 月至 6 月），对 150 名因异常实验室参数和外周涂片发现而经知情同意和伦理审查委员会批准建议进行骨髓检查的患者的数据进行研究，以找出异常血液学参数和抽吸结果之间的相关性，从而得出明确的诊断。使用 SPSS 版本 23.0 分析数据，包括基本人口统计学变量（年龄、性别等）、异常血液学参数（CBC）、外周涂片发现和抽吸发现。
在 150 名异常血液学参数的研究参与者中，24 名（16%）分别被诊断为急性白血病/霍奇金和非霍奇金淋巴瘤、13 名（9%）再生障碍性贫血和自身免疫性溶血性贫血、33 名（22%）脾功能亢进、慢性髓系白血病和多发性骨髓瘤。而 22 名（15%）被诊断为 CKD 和反应性变化的 BME。此外，22 名（15%）患者分别被诊断为缺铁性贫血。
研究表明，异常血液学参数的患者应进行骨髓检查以确定可能导致异常实验室参数的恶性和非恶性疾病的诊断。
