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布地奈德在儿童和青少年变应性鼻炎管理中的更新作用。

The updated role of budesonide in managing children and adolescents with allergic rhinitis.

机构信息

Allergy Clinic, Casa di Cura Villa Montallegro, Genoa, Italy -

出版信息

Minerva Pediatr (Torino). 2024 Aug;76(4):526-536. doi: 10.23736/S2724-5276.24.07538-4. Epub 2024 Feb 26.

Abstract

Allergic rhinitis (AR) is a prevalent disease in childhood and adolescence. A type 2 inflammation characterizes AR and, mainly, sustains nasal obstruction. Budesonide aqueous nasal spray (BANS) is an intranasal corticosteroid (INCS) available since the early 1980s. BANS is indicated for treating allergic rhinitis. There is evidence about its efficacy in treating children and adolescents with seasonal and perennial AR. In addition, BANS is safe with negligible local and systemic side effects. Recent guidelines for patients with AR recommend the use of INCS as first line in many situations. In particular, AR patients (and their parents) may assess the perception of symptoms' severity using the Visual Analog Scale (VAS). A score ≥5/10 means uncontrolled symptoms and requires adequate treatment. BANS could appropriately be used in patients with uncontrolled symptoms and/or moderate/severe nasal obstruction. In conclusion, BANS represents a valuable option in managing children and adolescents with AR.

摘要

变应性鼻炎(AR)是儿童和青少年中常见的疾病。2 型炎症是 AR 的特征,主要维持鼻阻塞。布地奈德水性鼻喷雾剂(BANS)是自 20 世纪 80 年代初以来可用的一种鼻内皮质类固醇(INCS)。BANS 用于治疗变应性鼻炎。有证据表明它在治疗季节性和常年性 AR 的儿童和青少年中的疗效。此外,BANS 具有安全性,几乎没有局部和全身副作用。最近的 AR 患者指南建议在许多情况下将 INCS 作为一线治疗药物。特别是,AR 患者(及其父母)可以使用视觉模拟评分(VAS)评估症状严重程度的感知。得分≥5/10 表示症状未得到控制,需要进行适当的治疗。BANS 可适用于症状未得到控制和/或中重度鼻阻塞的患者。总之,BANS 是治疗 AR 儿童和青少年的有价值的选择。

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