Department of Surgery, The University of Maryland School of Medicine, Baltimore, Maryland, USA.
Department of Surgery, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
Xenotransplantation. 2024 Jan-Feb;31(1):e12845. doi: 10.1111/xen.12845.
The 2023 IXA conference, hosted in San Diego, CA, brimmed with excitement against the backdrop of recent innovations in both the pre-clinical and clinical realms with several first-in-human applications of xenotransplantation. The theme, "Pigs are flying," alluded to the adage that xenotransplantation would only become a clinical reality "when pigs fly," suggesting a day that might never come. The event witnessed significant attendance, with 600 participants-the highest in the history of an IXA-IPITA joint congress. Among the attendees were members of the Food and Drug Administration (FDA), the National Institutes of Health (NIH), and corporate sponsors deeply engaged in the field. We summarize the latest topics from the congress, ranging from the pros/cons of decedent models of xenotransplantation and genetic engineering of porcine heart valves, solid organs, and cells for clinical translation and their regulatory and ethical landscape.
2023 年的 IXA 会议在加利福尼亚州圣地亚哥举行，会议背景是临床前和临床领域的最新创新，其中包括几项异种移植的首例人体应用，充满了兴奋。主题是“猪在飞”，暗指异种移植只有在“当猪飞起来”时才会成为临床现实，这表明这一天可能永远不会到来。此次活动的参与人数创下历史新高，达到 600 人，是 IXA-IPITA 联合大会历史上参与人数最多的一次。与会者包括美国食品和药物管理局（FDA）、美国国立卫生研究院（NIH）的成员以及深入参与该领域的公司赞助商。我们总结了大会的最新议题，包括异种移植尸源模型的利弊，以及基因工程猪心脏瓣膜、实体器官和细胞的临床转化及其监管和伦理景观。
