Drug Health Services, Western Health, Melbourne, Australia.
cohealth Innerspace, Melbourne, Australia.
Drug Alcohol Rev. 2024 May;43(4):1013-1018. doi: 10.1111/dar.13826. Epub 2024 Feb 26.
This case series records a cohort of patients treated with transdermal buprenorphine patches as part of a buprenorphine microdose induction protocol to transition from methadone to buprenorphine in a community setting. This has historically been a difficult process to manage in community settings and this case series explored a method to gradually manage this in an outpatient setting.
A retrospective file audit was conducted of the electronic medical records of cohealth Innerspace patients who had undergone buprenorphine microdose induction using transdermal patches. A total of 32 patients were identified.
In this case series 23 of the 32 patients successfully transitioned from methadone to sublingual or long-acting injectable depot buprenorphine preparations utilising the transdermal buprenorphine microdosing technique. All patients in this case series regardless of the success of the transition were retained in treatment.
A fixed-dose transdermal buprenorphine patch regimen enabled 23 of 32 patients in this case series transition from methadone to buprenorphine in an outpatient setting. Given the small sample size further research is required to demonstrate the effectiveness of this technique.
本病例系列记录了一组接受透皮丁丙诺啡贴片治疗的患者，他们是丁丙诺啡微剂量诱导方案的一部分，以在社区环境中从美沙酮过渡到丁丙诺啡。在社区环境中管理这一过程历来具有挑战性，本病例系列探讨了一种在门诊环境中逐渐管理这一过程的方法。
对 cohealth Innerspace 使用透皮贴片进行丁丙诺啡微剂量诱导的患者的电子病历进行回顾性文件审核。共确定了 32 名患者。
在本病例系列中，23 名患者成功地从美沙酮过渡到舌下或长效注射丁丙诺啡制剂，使用了透皮丁丙诺啡微剂量技术。本病例系列中的所有患者，无论过渡是否成功，均保留在治疗中。
固定剂量透皮丁丙诺啡贴片方案使本病例系列中的 32 名患者中的 23 名能够在门诊环境中从美沙酮过渡到丁丙诺啡。鉴于样本量较小，需要进一步研究来证明该技术的有效性。
