Aitken R J, Clarkson J S, Irvine D S, Richardson D W
Acta Eur Fertil. 1985 Jul-Aug;16(4):273-80.
The nature and significance of some biologically orientated tests of human sperm function is discussed by the Authors. In particular tests for motility and the fertilizing capacity of spermatozoa are examined, motility tests and the zona-free hamster oocyte penetration test are particularly criticized. The Authors affirm that hamster oocyte tests carried out in the presence of A 23187 have shown to correlate with fertility in vivo and may be of critical value in decreasing the incidence of false negative scores. The data furnished by this test will provide a logical basis for discovering the aetiology of male infertility as well as devising techniques to both detect and treat these conditions.
作者们讨论了一些以生物学为导向的人类精子功能测试的性质和意义。特别是对精子活力和受精能力的测试进行了研究，活力测试和无透明带仓鼠卵母细胞穿透试验受到了特别批评。作者们断言，在A 23187存在的情况下进行的仓鼠卵母细胞试验已显示与体内生育力相关，并且在降低假阴性评分发生率方面可能具有关键价值。该测试提供的数据将为发现男性不育的病因以及设计检测和治疗这些病症的技术提供逻辑依据。
