Department of Natural Products, Faculty of Pharmacy, King Abdulaziz University, Jeddah, 21589, Saudi Arabia.
Centre for Artificial Intelligence in Precision Medicines, King Abdulaziz University, Jeddah, 21589, Saudi Arabia.
Arch Microbiol. 2024 Feb 27;206(3):124. doi: 10.1007/s00203-024-03900-0.
Quorum sensing (QS) is a communication mechanism employed by many bacteria to regulate gene expression in a population density-dependent manner. It plays a crucial role in coordinating various bacterial behaviors, including biofilm formation, virulence factor production, and antibiotic resistance. However, the dysregulation of QS can lead to detrimental effects, making it an attractive target for developing novel therapeutic strategies. Anti-QS approaches aim to interfere with QS signaling pathways, inhibiting the communication between bacteria, and disrupting their coordinated activities. Various strategies have been explored to achieve this goal. Advances in understanding QS mechanisms and the discovery of new targets have paved the way for the development of innovative anti-QS approaches. Combining multiple anti-QS strategies or utilizing them in combination with traditional antibiotics holds great promise for combating bacterial infections and addressing the challenges posed by antibiotic resistance. Anti-QS approaches offer a diverse range of strategies including natural compounds, antibody-mediated quorum quenching (QQ), computer-aided drug design for QQ, repurposing of Drugs approved by FDA as anti-QS agents and modulating quorum-sensing molecules which were discussed in detail in this review. This review, comprehensively and for the first time, sheds light on the significance of diverse anti-QS strategies in solving antimicrobial resistance problem in Gram-negative microbial infection.
群体感应 (QS) 是许多细菌用来以种群密度依赖的方式调节基因表达的一种通讯机制。它在协调各种细菌行为方面起着至关重要的作用，包括生物膜形成、毒力因子产生和抗生素耐药性。然而，QS 的失调可能会导致有害影响，使其成为开发新型治疗策略的有吸引力的目标。抗 QS 方法旨在干扰 QS 信号通路，抑制细菌之间的通讯，并破坏它们的协调活动。已经探索了各种策略来实现这一目标。对 QS 机制的理解的进步和新靶点的发现为开发创新的抗 QS 方法铺平了道路。结合多种抗 QS 策略或将它们与传统抗生素联合使用，为对抗细菌感染和解决抗生素耐药性带来的挑战提供了巨大的希望。抗 QS 方法提供了多种策略，包括天然化合物、抗体介导的群体感应淬灭 (QQ)、用于 QQ 的计算机辅助药物设计、将 FDA 批准的药物重新用于抗 QS 剂以及调节群体感应分子，本综述详细讨论了这些策略。本综述首次全面地阐明了多种抗 QS 策略在解决革兰氏阴性微生物感染中的抗生素耐药性问题方面的重要性。
