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[吸入麻醉药动力学的建模与BASIC程序]

[Modeling and BASIC program for the kinetics of inhalation anesthetic agents].

作者信息

Deriaz H, Lienhart A, Viars P

出版信息

Ann Fr Anesth Reanim. 1985;4(5):406-12. doi: 10.1016/s0750-7658(85)80270-7.

Abstract

The pharmacokinetics of inhaled anaesthetics has been well described by Eger's model using a monoalveolar lung with continuous alveolar ventilation and four extrapulmonary compartments defined by their blood supply and anaesthetic solubility. The model is presented with its equations. A Basic microcomputer programme is proposed for this model: expected concentrations of anaesthetic in various conditions of administration, ventilation or cardiac output are shown, such as the uptake and distribution of nitrous oxide during anaesthesia. Different inhaled anaesthetics were compared for induction and recovery times in standardized conditions of administration.

摘要

吸入麻醉药的药代动力学已由埃杰尔模型很好地描述,该模型使用具有连续肺泡通气的单肺泡肺以及由其血液供应和麻醉药溶解度定义的四个肺外隔室。文中给出了该模型及其方程式。针对此模型提出了一个基本的微机程序:展示了在各种给药、通气或心输出量条件下麻醉药的预期浓度,比如麻醉期间氧化亚氮的摄取和分布。在标准化给药条件下比较了不同吸入麻醉药的诱导和恢复时间。

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