Vanreusel Inne, Hens Wendy, Van Craenenbroeck Emeline, Van Berendoncks An, Segers Vincent F M
Department of Cardiology, Antwerp University Hospital, 2650 Edegem, Belgium.
Research Group Cardiovascular Diseases, GENCOR, University of Antwerp, 2610 Antwerp, Belgium.
Curr Cardiol Rev. 2024;20(4):e210224227260. doi: 10.2174/011573403X278440240209064408.
Although there is a continually growing number of patients with congenital heart disease (CHD) due to medical and surgical advances, these patients still have a poorer prognosis compared to healthy individuals of similar age. In patients with heart failure, microvascular dysfunction (MVD) has recently emerged as a crucial modulator of disease initiation and progression. Because of the substantial pathophysiological overlap between CHD and heart failure induced by other etiologies, MVD could be important in the pathophysiology of CHD as well. MVD is believed to be a systemic disease and may be manifested in several vascular beds. This review will focus on what is currently known about MVD in the peripheral vasculature in CHD. Therefore, a search on the direct assessment of the vasodilatory capacity of the peripheral microcirculation in patients with CHD was conducted in the PubMed database. Since there is little data available and the reported studies are also very heterogeneous, peripheral MVD in CHD is not sufficiently understood to date. Its exact extent and pathophysiological relevance remain to be elucidated in further research.
尽管由于医学和外科手术的进步，先天性心脏病（CHD）患者的数量在持续增加，但与年龄相仿的健康个体相比，这些患者的预后仍然较差。在心力衰竭患者中，微血管功能障碍（MVD）最近已成为疾病发生和进展的关键调节因素。由于CHD与其他病因引起的心力衰竭之间存在大量病理生理重叠，MVD在CHD的病理生理学中可能也很重要。MVD被认为是一种全身性疾病，可能在多个血管床中表现出来。本综述将聚焦于目前已知的CHD外周血管系统中的MVD情况。因此，在PubMed数据库中对CHD患者外周微循环血管舒张能力的直接评估进行了检索。由于可用数据很少，且所报道的研究也非常异质性，迄今为止，CHD中的外周MVD尚未得到充分了解。其确切程度和病理生理相关性仍有待进一步研究阐明。
