Rodrigues Juliano Flávio Rubatino, Rodrigues Livia Peregrino, de Araújo Filho Gerardo Maria
Faculdade de Medicina de Marília (FAMEMA), Marília, SP, Brazil.
Faculdade de Medicina de São José do Rio Preto (FAMERP), São José do Rio Preto, SP, Brazil.
Curr Alzheimer Res. 2024;20(11):758-768. doi: 10.2174/0115672050292472240216052614.
Suicide has been described in patients with Alzheimer's disease. Some promising medications for treating Alzheimer's disease have had their studies suspended because they increase the risk of suicide. Understanding the correlations between suicide and Alzheimer's disease is essential in an aging world.
A search was carried out on electronic websites (PubMed and Scielo) using the MeSH Terms "suicide" and "Alzheimer" (1986-2023). Of a total of 115 articles, 26 were included in this review.
Depression and the allele ε4 of Apolipoprotein (APOE4) were demonstrated to be the main risk factors for suicide in patients with Alzheimer's disease.
Adequately delineating which elderly people are vulnerable to suicide is important so that new treatments for Alzheimer's disease can be successful. This review showed a need for new studies to investigate the interface between Alzheimer's disease and suicide.
阿尔茨海默病患者中存在自杀现象。一些治疗阿尔茨海默病的有前景的药物研究已被暂停，因为它们会增加自杀风险。在老龄化社会中，了解自杀与阿尔茨海默病之间的关联至关重要。
在电子网站（PubMed和Scielo）上使用医学主题词“自杀”和“阿尔茨海默病”进行检索（1986 - 2023年）。在总共115篇文章中，本综述纳入了26篇。
抑郁症和载脂蛋白ε4等位基因（APOE4）被证明是阿尔茨海默病患者自杀的主要危险因素。
明确哪些老年人易发生自杀很重要，这样阿尔茨海默病的新治疗才能取得成功。本综述表明需要开展新的研究来探究阿尔茨海默病与自杀之间的关系。
